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Production of rare sugars by the subcritical treatment in aqueous polyols

Research Project

Project/Area Number 17K07814
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

Kobayashi Takashi  京都大学, 農学研究科, 助教 (70416311)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords亜臨界水 / 希少糖 / 緩衝液 / 異性化 / 有機酸 / 速度解析 / 亜臨界流体 / ポリオール / 配位子交換クロマトグラフィー
Outline of Final Research Achievements

Subcritical water is a highly reactive yet harmless solvent. When an attempt was made to synthesize rare sugars from common sugars by subcritical water treatment, almost no rare sugars were produced. However, the addition of ethanol to water improved the yield of rare sugars, although the addition of ethanol decreases the solubility of sugars in a medium. Therefore, aqueous polyols were adopted for the production. However, since no significant improvement in the rare sugar yield was observed, we attempted to synthesize rare sugars in a subcritical water containing phosphate buffer. As a result, significant improvement in the yield of rare sugars of 10 times or more was observed as compared with the conventional methods.

Academic Significance and Societal Importance of the Research Achievements

希少糖は自然界に存在量の少ない糖類の総称である。希少糖の中には有用な生理活性を持つものがあると考えられているが、現在のところ機能性を評価するための希少糖生産プロセスは確立されていない。そこで、我々は亜臨界流体中で希少糖の合成を試みた。リン酸緩衝液を反応溶媒にすることで、低温で迅速に、かつ効率的に希少糖を合成できた。これは、健康増進社会の推進に寄与するとともに、省エネルギーで環境負荷の小さい希少糖生産プロセスでもある。種々の希少糖の製造が実現することにより、持続可能な社会の実現に寄与することが出来、SDGsにも見合う。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Isomerization and Epimerization of Galactose to Tagatose and Talose in a Phosphate Buffer Containing Organic Solvents under Subcritical Water Conditions2021

    • Author(s)
      Onishi Yuichiro、Furushiro Yuya、Adachi Shuji、Kobayashi Takashi
    • Journal Title

      Industrial & Engineering Chemistry Research

      Volume: - Issue: 14 Pages: 5084-5089

    • DOI

      10.1021/acs.iecr.1c00682

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reaction Behavior of Glucose and Fructose in Subcritical Water in the Presence of Various Salts2020

    • Author(s)
      Furushiro Yuya、Kobayashi Takashi
    • Journal Title

      Journal of Applied Glycoscience

      Volume: 67 Issue: 1 Pages: 11-15

    • DOI

      10.5458/jag.jag.JAG-2019_0014

    • NAID

      130007800423

    • ISSN
      1344-7882, 1880-7291
    • Year and Date
      2020-02-20
    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Production of Tagatose from Galactose in a Batch-type Reactor Using a Phosphate Buffer under Subcritical Water Conditions2020

    • Author(s)
      S. Adachi, Y. Miyagawa, T. Kobayashi
    • Journal Title

      Food Science and Technology Research

      Volume: 26 Issue: 6 Pages: 695-699

    • DOI

      10.3136/fstr.26.695

    • NAID

      130007962128

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production of tagatose and talose through isomerization of galactose in a buffer solution under subcritical water conditions2020

    • Author(s)
      Onishi Yuichiro、Furushiro Yuya、Hirayama Yusuke、Adachi Shuji、Kobayashi Takashi
    • Journal Title

      Carbohydrate Research

      Volume: 493 Pages: 108031-108031

    • DOI

      10.1016/j.carres.2020.108031

    • NAID

      120006844938

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics for the Subcritical Treatment of Glucose Solution at Various Concentrations2019

    • Author(s)
      Hirayama Yusuke、Kobayashi Takashi
    • Journal Title

      Food Science and Technology Research

      Volume: 25 Issue: 3 Pages: 383-389

    • DOI

      10.3136/fstr.25.383

    • NAID

      130007690060

    • ISSN
      1344-6606, 1881-3984
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kinetics for the subcritical treatment of glucose solution at various concentrations2019

    • Author(s)
      Y. Hirayama, T. Kobayashi
    • Journal Title

      Food Science and Technology Research

      Volume: 印刷中

    • NAID

      130007690060

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 亜臨界水中での希少糖の合成に及ぼす緩衝液とアルコールの影響2021

    • Author(s)
      尾西 佑一朗、古城 侑也、安達 修二、谷 史人、小林 敬
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 亜臨界水中でのグルコース濃度が異性化反応に及ぼす影響2018

    • Author(s)
      平山祐輔,小林敬,谷史人
    • Organizer
      日本農芸化学会2018年度(平成30年度)大会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 希少単糖および希少二糖の製造方法2019

    • Inventor(s)
      小林敬、平山祐輔、古城侑也、尾西佑一朗
    • Industrial Property Rights Holder
      小林敬、平山祐輔、古城侑也、尾西佑一朗
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2017-04-28   Modified: 2022-01-27  

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