| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we performed development of analytical method and elucidation of physiological functions of sulfated polysaccharides such as fucoidan. As the results, a series of compounds that interact with sulfate groups to change the nuclear magnetic resonance (NMR) signal were found, and constructed a new quantitative method for rapid determination of sulfate content. In addition, a mechanism by which fucoidan acts on the cell membrane to activate immune cells was clarified. Furthermore, it was revealed that fucoidan enhanced antitumor immunity and suppressed cancerous angiogenesis through activation of intestinal immune cells and improvement of intestinal environment.
|
