Trade-off relationships among growth, seawater-adaptation, and disease resistance through antagonistic effects of endocrine factors in salmonid

• Project/Area Number: 17K07950
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Aquatic life science
• Research Institution: Fisheries Research and Education Agency
• Principal Investigator: Yada Takashi 国立研究開発法人水産研究・教育機構, 中央水産研究所, グループ長 (80372043)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生理 / 水産学 / 回遊 / 行動

Outline of Final Research Achievements

Changes in endocrine and immune systems during downstream migration in salmonids were investigated in aspects of antagonistic effects of endocrine factors with reference to growth, seawater-adaptation, and disease resistance. Development of seawater-adaptability has been observed even in land-locked forms. Results in seawater-acclimation of sea-run form imply harmonization of gene expression among hormone-receptors relating to growth, seawater-adaptation, and disease resistance. On the other hand, the immune system was influenced by sustained stress through the cortisol receptor-mediated pathway.

Academic Significance and Societal Importance of the Research Achievements

サケ科魚類における成長と海水適応の内分泌調節が免疫系に及ぼす影響について、ホルモン受容体遺伝子の制御による協調的な関係としての理解を進めることができた。またストレスによる免疫機能の抑制現象について、細胞内での分子機構の解析が進んだ。これらの成果により、サケ科魚類の人工孵化・稚魚放流後の生残率を高める技術の開発とともに、海面等での養殖技術のさらなる高度化・効率化に資する知見を得ることができた。

Research Products

• [Journal Article] Down-regulation of corticosteroid receptor in leucocytes of stressed rainbow trout (2019)
  • Author(s): Yada Takashi、Abe Michihisa、Miyamoto Kouta
  • Journal Title: General and Comparative Endocrinology Volume: 280 Pages: 54-61
  • DOI: 10.1016/j.ygcen.2019.04.011
  • Peer Reviewed
• [Journal Article] Thermal tolerance of a thermally selected strain of rainbow trout Oncorhynchus mykiss and the pedigrees of its F1 and F2 generations indicated by their critical thermal maxima (2018)
  • Author(s): Ineno Toshinao、Tamaki Koichi、Yamada Kazuya、Kodama Ryusuke、Tsuchida Shuji、Tan Engkong、Kinoshita Shigeharu、Muto Koji、Yada Takashi、Kitamura Shoji、Asakawa Shuichi、Watabe Shugo
  • Journal Title: Fisheries Science Volume: 84 Issue: 4 Pages: 671-679
  • DOI: 10.1007/s12562-018-1217-2
  • NAID: 40021587927
  • Peer Reviewed
• [Presentation] ストレス負荷ニジマスの白血球における副腎皮質ホルモン受容体の抑制的制御． (2019)
  • Author(s): 矢田 崇，阿部倫久，宮本幸太
  • Organizer: 日本動物学会大会第90回大会，大阪
• [Presentation] 海水馴致スチールヘッドトラウトの鰓・表皮・腸管・白血球におけるホルモン受容体と免疫関連遺伝子の発現動態． (2019)
  • Author(s): 矢田 崇，阿部倫久
  • Organizer: 第44回日本比較内分泌学会，浦和
• [Presentation] アユ・サケ・ウナギの移動／定着とストレス応答 (2018)
  • Author(s): 矢田 崇
  • Organizer: 第43回日本比較内分泌学会
  • Invited
• [Presentation] Down-regulation of corticosteroid receptors in leucocytes of stressed rainbow trout with reference to proliferative and apoptotic conditions (2018)
  • Author(s): Yada, T., Miyamoto, K., Abe, M.
  • Organizer: The 8th Intercongress meeting of Asia Oceania Society for Comparative Endocrinology
  • Int'l Joint Research / Invited
• [Presentation] サケ科魚類の降海性との関係から見たホンマスの海水適応能力 (2017)
  • Author(s): 矢田 崇
  • Organizer: サラマオマス発見100周年記念国際シンポジウム
  • Int'l Joint Research
• [Book] International symposium on the discovery of Formosa landlocked salmon’s 100th anniversary. (2019)
  • Author(s): Yada, T., Abe, M.
  • Total Pages: 6
  • Publisher: National Taiwan Museum, Taipei
• [Book] Immune system of teleosts (Actinopterygii), in “Advances in Comparative Immunology” (2018)
  • Author(s): Nakanishi, T., Hikima, J., Yada, T.
  • Total Pages: 1048
  • Publisher: Springer
  • ISBN: 9783319767680