Chemokine cross talk mechanism between endometrium and immune cells during the maternal recognition in cows

• Project/Area Number: 17K08056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: SAKUMOTO RYOSUKE 国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門, 上級研究員 (20343999)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 繁殖 / 牛 / ケモカイン / 妊娠 / 子宮 / 遺伝子 / 家畜 / 動物 / 生理学 / 細胞・組織

Outline of Final Research Achievements

The expression of chemokine genes is increased in the endometrium (CCL2, CCL8, CCL14, CCL16, CXCL10) and immune cells (CCL8, CXCL10) during early pregnancy. Both CCL8 and CXCL10 also induce chemotaxis of immune cells. These findings suggest that the chemokine cross talk system plays important roles at the time of maternal recognition in cows.

Academic Significance and Societal Importance of the Research Achievements

妊娠認識時の牛子宮内膜および免疫細胞間におけるケモカインクロストーク機構の解明により、長年の課題である早期胚死滅に起因する受胎率低下の改善に向けた、妊娠初期胚の生存性や機能更新、子宮への着床を誘起するためのケモカインを用いた新たな繁殖機能制御技術の開発などにつながることが期待される。

Research Products

• [Journal Article] Pregnancy-associated changes of peroxisome proliferator-activated receptor delta (PPARD) and cytochrome P450 family 21 subfamily A member 2 (CYP21A2) expression in the bovine corpus luteum (2020)
  • Author(s): SAKUMOTO Ryosuke、HAYASHI Ken-Go、HOSOE Misa、IGA Kosuke、KIZAKI Keiichiro
  • Journal Title: Journal of Reproduction and Development Volume: 66 Issue: 3 Pages: 205-213
  • DOI: 10.1262/jrd.2019-132
  • NAID: 130007853980
  • ISSN: 0916-8818, 1348-4400
  • Peer Reviewed / Open Access
• [Journal Article] Gene expression of CCL8 and CXCL10 in peripheral blood leukocytes during early pregnancy in cows (2018)
  • Author(s): Sakumoto Ryosuke、Iga Kosuke、Hayashi Ken-Go、Fujii Shiori、Kanahara Hiroko、Hosoe Misa、Furusawa Tadashi
  • Journal Title: Journal of Animal Science and Biotechnology Volume: 9 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s40104-018-0263-z
  • Peer Reviewed / Open Access