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Pathogenesis study of neurological diseases in calves

Research Project

Project/Area Number 17K08072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

Kobayashi Yoshiyasu  帯広畜産大学, 畜産学部, 教授 (20301971)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords周産期脳障害 / 神経傷害マーカー / 低酸素マーカー / 小脳皮質変性症 / ウシ / 小脳 / Fluoro Jade C / 病理 / 子牛 / 神経疾患 / 周産期 / 低酸素 / 大脳皮質壊死 / 免疫組織化学 / DNAマイクロアレイ
Outline of Final Research Achievements

The present study revealed that periventricular leukomalacia, cerebral cortical necrosis, and bilateral focal symmetrical encephalomalacia (necrosis of basal ganglia) were seen also in cattle as perinatal brain damages. Fluoro Jade C, a nerve injury marker, Alzheimer precursor protein A4, an axonal degeneration marker, and Hypoxia inducible factor-1a and vascular endothelial growth factor, both a hypoxic marker, were useful for detecting these lesions. These markers were useful to visualize the lesions of an encephalopathy without obvious histopathological changes in some cases. Histopathological features of bovine cerebellar cortical degeneration were also clarified in the present research.

Academic Significance and Societal Importance of the Research Achievements

本研究により、これまで良く知られていなかった周産期脳障害がウシにも存在することが明らかになった。また、神経傷害マーカーや低酸素マーカーがウシでも適用できることを示すとともに、ウシの小脳皮質変性症の特徴所見を明らかにすることができた。これらの知見は、今後の症例診断に有用な情報を与えるものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (2 results)

  • [Int'l Joint Research] Cornell University/College of Veterinary Medicine(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Organ blood flow in response to infusion of arginine vasopressin in premature fetal sheep2020

    • Author(s)
      Watanabe S, Matsuda T, Hanita T, Ikeda H, Koshinami S, Sato S, Usuda H, Saito M, Kemp MW, Kobayashi Y
    • Journal Title

      Pediatr Int

      Volume: - Issue: 6 Pages: 688-693

    • DOI

      10.1111/ped.14141

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebellar Cortical Degeneration in a Cross-Breed Calf2019

    • Author(s)
      ANRAKU Mizuki、UESAKA Karin、FUJII Sakiko、KOYAMA Kenji、KOBAYASHI Yoshiyasu、INOKUMA Hisashi
    • Journal Title

      Journal of the Japan Veterinary Medical Association

      Volume: 72 Issue: 3 Pages: 154-156

    • DOI

      10.12935/jvma.72.154

    • NAID

      130007635262

    • ISSN
      0446-6454, 2186-0211
    • Year and Date
      2019-03-20
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supplemental study on 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone2019

    • Author(s)
      Kanno T, Kurotaki T, Yamada N, Tomonari Y, Sato J, Tsuchitani M, Kobayashi Y
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 9 Pages: 1368-1372

    • DOI

      10.1292/jvms.19-0096

    • NAID

      130007725684

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 先天性門脈体循環シャントにより肝性脳症を呈したホルスタイン種子牛の1症例2019

    • Author(s)
      森山 咲, 千葉 汐莉, 上坂 花鈴, 串間 宏充, 渡邉 謙一, 堀内 雅之, 古林 与志安, 猪熊 壽
    • Journal Title

      産業動物臨床医誌

      Volume: 10 Pages: 73-77

    • NAID

      130007719099

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 椎体膿瘍および椎体周囲膿瘍による腰椎病的骨折のホルスタイン種育成牛にみられた後躯麻痺の1症例2019

    • Author(s)
      村田 芙花, 中郡 翔太郎, 橋元 直也, 渡邉 謙一, 堀内 雅之, 古林 与志安, 都築 直, 猪熊 壽
    • Journal Title

      産業動物臨床医誌

      Volume: 10 Pages: 22-25

    • NAID

      130007664946

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated neuron-specific enolase in the cerebrospinal fluid in a Japanese black calf with hindlimb paresis2018

    • Author(s)
      Uesaka K.、Koyama K.、Horiuchi N.、Kobayashi Y.、Inokuma H.
    • Journal Title

      Japanese Journal of Large Animal Clinics

      Volume: 9 Issue: 1 Pages: 12-15

    • DOI

      10.4190/jjlac.9.12

    • NAID

      130007644359

    • ISSN
      1884-684X, 2187-2805
    • Year and Date
      2018-06-30
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histopathological study of encephalomalacia in neonatal calves and application of neuronal and axonal degeneration marker2018

    • Author(s)
      KOYAMA Kenji、KANGAWA Akihisa、FUKUMOTO Natsuko、WATANABE Ken-ichi、HORIUCHI Noriyuki、OZAWA Tomomi、INOKUMA Hisashi、KOBAYASHI Yoshiyasu
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 7 Pages: 1116-1124

    • DOI

      10.1292/jvms.18-0143

    • NAID

      130007404167

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A clinical case of enzootic bovine leukosis in a 13-month-old Holstein heifer2018

    • Author(s)
      Maezawa M, Watanabe K, Horiuchi N, Matsumoto K, Kobayashi Y, and Inokuma H.
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 66 Issue: 3 Pages: 209-213

    • DOI

      10.14943/jjvr.66.3.209

    • NAID

      120006540768

    • ISSN
      0047-1917
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves2018

    • Author(s)
      Tanaka Yusuke、Toyotome Takahito、Inokuma Hisashi、Watanabe Ken-ichi、Kobayashi Yoshiyasu、Horiuchi Noriyuki
    • Journal Title

      Mycopathologia

      Volume: 184 Issue: 1 Pages: 141-146

    • DOI

      10.1007/s11046-018-0296-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pure red cell aplasia in a Holstein calf.2018

    • Author(s)
      Maezawa, M., Koyama, K., Horiuchi, N., Kobayashi, Y. and Inokuma, H.
    • Journal Title

      Comparative Clinical Pathology

      Volume: 27(1) Issue: 1 Pages: 253-255

    • DOI

      10.1007/s00580-017-2586-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A clinical case of neosporosis in a 4-week-old holstein friesian calf which developed hindlimb paresis postnatally2018

    • Author(s)
      Uesaka, K., Koyama, K., Horiuchi, N., Kobayashi, Y., Nishikawa, Y. and Inokuma H.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 280-283

    • DOI

      10.1292/jvms.17-0205

    • NAID

      130006386447

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 重複脊髄症により後躯麻痺を呈したホルスタイン種子牛の1症例.2017

    • Author(s)
      安樂みずき, 入江遥, 下タ村圭一, 小山憲司, 渡邉謙一, 堀内雅之, 古林与志安, 山田一孝, 猪熊壽.
    • Journal Title

      獣医畜産新報

      Volume: 70(6) Pages: 441-444

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pericardial mesothelioma with severe congestive heart failure in a Holstein cow2017

    • Author(s)
      Suzuki, H., Watanabe, K., Horiuchi, N., Kobayashi, Y. and Inokuma, H.
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 65 Issue: 3 Pages: 167-172

    • DOI

      10.14943/jjvr.65.3.167

    • NAID

      120006346125

    • ISSN
      0047-1917
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 新生子仮死の病歴を有する子牛の脳病変とその同定方法に関する検討2017

    • Author(s)
      小山憲司、寒川彰久、福本奈津子、渡邉謙一、堀内雅之、猪熊壽、 古林与志安
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 子牛の小脳皮質変性症に関する免疫組織学的検討2017

    • Author(s)
      藤井沙希子、小山憲司、渡邉謙一、堀内雅之、古岡秀文、猪熊壽、 古林与志安
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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