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Evolutionary epidemiological study aimed at preventing the spread of vampire bat-related rabies

Research Project

Project/Area Number 17K08086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionNihon University

Principal Investigator

SAKAI Takeo  日本大学, 生物資源科学部, 名誉教授 (50147667)

Co-Investigator(Kenkyū-buntansha) 伊藤 琢也  日本大学, 生物資源科学部, 教授 (20307820)
鈴木 由紀  日本大学, 生物資源科学部, 准教授 (30712492)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords吸血コウモリ / 狂犬病ウイルス / 分子疫学 / 次世代シーケンサー / 進化 / 疫学
Outline of Final Research Achievements

This study aimed to elucidate the spread of the vampire-derived rabies virus (RABV) from the viewpoint of molecular epidemiology, and proceeded to decipher the RABV genome by a next-generation sequencer (NGS). The nucleotide sequence region that could not be sequenced by NGS analysis was decoded by the Sanger sequencing. The insectivorous bat Tadarida brasiliensis is widely distributed from North America to South America, but as a result of molecular phylogenetic analysis, vampire bats were transmitted RABV from a population of T. brasiliensis distributed in North and Central America, and then RABV was transmitted southward. It was then speculated that RABV was widely spread to a population of vampire bats in various regions of Brazil, and that RABV was also transmitted to the frugivorous bat (genus Artibeus) during the spread process.

Academic Significance and Societal Importance of the Research Achievements

本研究は、現在南米の家畜で流行している狂犬病の主要な媒介動物である吸血コウモリから分離された狂犬病ウイルスの分子疫学的解析を行ったことにより、その起源が北中米の食虫コウモリであることを明らかにした。分子系統樹解析の結果、この狂犬病ウイルスは中米から南米に吸血コウモリの集団に伝播する形で南下して拡散し、その過程で異種の食果コウモリへの伝搬が起こったと考えられた。このような吸血コウモリ由来感染症の拡散様式や異種伝搬を明らかにしたことは、現在課題となっている多くのコウモリ関連人獣共通感染症の制御を考える上で重要な情報を提供した。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (4 results) Book (2 results)

  • [Int'l Joint Research] サンパウロ大学/サンパウロ州立パウリスタ大学(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] サンパウロ大学/サンパウロ州立パウリスタ大学(ブラジル)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] サンパウロ大学/サンパウロ州立パウリスタ大学(ブラジル)

    • Related Report
      2017 Research-status Report
  • [Journal Article] Heritability estimates of the position and number of facial hair whorls in Thoroughbred horses2019

    • Author(s)
      Yokomori Tamu、Tozaki Teruaki、Mita Hiroshi、Miyake Takeshi、Kakoi Hironaga、Kobayashi Yuki、Kusano Kanichi、Itou Takuya
    • Journal Title

      BMC Research Notes

      Volume: 12 Issue: 1 Pages: 346-346

    • DOI

      10.1186/s13104-019-4386-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A highly flexible and repeatable genotyping method for aquaculture studies based on target amplicon sequencing using next-generation sequencing technology2019

    • Author(s)
      Sato Mana、Hosoya Sho、Yoshikawa Sota、Ohki Shun、Kobayashi Yuki、Itou Takuya、Kikuchi Kiyoshi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6904-6904

    • DOI

      10.1038/s41598-019-43336-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An endogenous adeno-associated virus element in elephants2019

    • Author(s)
      Kobayashi Yuki、Shimazu Tsukika、Murata Koichi、Itou Takuya、Suzuki Yoshiyuki
    • Journal Title

      Virus Research

      Volume: 262 Pages: 10-14

    • DOI

      10.1016/j.virusres.2018.04.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Next-generation Sequencing Analysis of Bacterial Flora in Bovine <I>Prototheca</I> Mastitic Milk2018

    • Author(s)
      Kano Rui、Kobayashi Yuki、Nishikawa Akitoyo、Murata Ryo、Itou Takuya、Ito Takaaki、Suzuki Kazuyuki、Kamata Hiroshi
    • Journal Title

      Medical Mycology Journal

      Volume: 59 Issue: 3 Pages: E41-E46

    • DOI

      10.3314/mmj.18-00004

    • NAID

      130007473068

    • ISSN
      2185-6486, 2186-165X
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular Function Analysis of Rabies Virus RNA Polymerase L Protein by Using an L Gene-Deficient Virus.2017

    • Author(s)
      Nakagawa K, Kobayashi Y, Ito N, Suzuki Y, Okada K, Makino M, Goto H, Takahashi T, Sugiyama M.
    • Journal Title

      J Virol.

      Volume: 91 Issue: 20

    • DOI

      10.1128/jvi.00826-17

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] LPSで刺激されたイルカPBMCにおける炎症性サイトカインの発現動態2019

    • Author(s)
      二見健人、小林由紀、遠藤智子、伊藤琢也
    • Organizer
      第25回日本野生動物医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 飼育下アザラシにおける腸内細菌叢のメタ16S rRNA解析2019

    • Author(s)
      中曽根英、鈴木亮彦、岡崎雅子、R. Jory Brinkerfoff、佐藤真伍、小林由紀、伊藤琢也
    • Organizer
      第25回日本野生動物医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] アフリカ獣上目動物におけるボルナウイルス由来エレメントの蛋白質機能2018

    • Author(s)
      小林由紀
    • Organizer
      日本進化学会 第20回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] バンドウイルカから分離された腸内定着性に優れた乳酸菌の探索2018

    • Author(s)
      青柳皓大,瀬川太雄,鈴木美和, 岩田秀一,澤 修作,加来雅人,駒場昌幸,小林由紀,伊藤琢也
    • Organizer
      第24回日本野生動物医学会
    • Related Report
      2018 Research-status Report
  • [Book] 動物の衛生 第2版2020

    • Author(s)
      末吉 益雄、高井 伸二
    • Total Pages
      312
    • Publisher
      文永堂出版
    • ISBN
      9784830041396
    • Related Report
      2019 Annual Research Report
  • [Book] Laboratory Techniques in Rabies, Fifth Edition, Volume 2. (Eds) Charles E Rupprecht, Anthony R Fooks, Bernadette2019

    • Author(s)
      Itou T, Markotter W, Nel LH.
    • Total Pages
      202
    • Publisher
      World Health Organization
    • ISBN
      9789241515306
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2022-02-22  

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