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Cellular and molecular basis for body temperature control system in hamster, a postnatal homeotherm animal model

Research Project

Project/Area Number 17K08118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionHokkaido University

Principal Investigator

Okamatsu-Ogura Yuko  北海道大学, 獣医学研究院, 准教授 (90527178)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords褐色脂肪 / 体温調節 / UCP1 / ハムスター / 脂肪組織 / 熱産生 / 組織リモデリング / 冬眠動物 / 脂肪細胞 / 生後発達 / 脱共役タンパク質 / エネルギー代謝
Outline of Final Research Achievements

The body temperature of a homeothermic animal is regulated by the balance between heat production and heat dissipation. In this study, the mechanism of the development of brown adipose tissue that is responsible for non-shivering thermogenesis was investigated using hamsters, which is a advantageous model to investigate the effect of internal and external factors on the tissue formation. It was revealed that the speed of brown adipose tissue formation was controlled by ambient temperature, but the formation itself was controlled by endogenous secretory factors in hamsters. These result may contribute to the understanding of the mechanism for the construction of a body temperature control system in mammals, and also provide new insights for applied research toward the development of therapeutic tool against metabolic syndrome.

Academic Significance and Societal Importance of the Research Achievements

出生後に外温性から恒温性に転換する特殊なモデル動物であるハムスターにおける褐色脂肪組織の形成機構を理解することにより、哺乳動物に普遍的な体温制御システムの構築機構の理解に貢献できる。また、褐色脂肪組織は脂肪エネルギーを消費するため、肥満対策のターゲットとしても関心を集めている。本研究により見出された褐色脂肪組織形成を促進する因子は、褐色脂肪量を維持または増加させて太りにくい体質を獲得する新たなメタボリックシンドローム対策法の提示に向けた応用研究に活用できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (37 results)

All 2020 2019 2018 2017 Other

All Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 13 results,  Acknowledgement Compliant: 1 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (1 results)

  • [Journal Article] The effect of temperature acclimation on torpor expression pattern in mice2020

    • Author(s)
      Sakamoto KQ, Okamatsu-Ogura Y
    • Journal Title

      Japanese Journal of Veterinary Research

      Volume: 68 Issue: 1 Pages: 55-62

    • DOI

      10.14943/jjvr.68.1.51

    • NAID

      120006796039

    • ISSN
      0047-1917
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of circulating exosomal miR-122 levels with BAT activity in healthy humans2019

    • Author(s)
      Okamatsu-Ogura Yuko、Matsushita Mami、Bariuan Jussiaea Valente、Nagaya Kazuki、Tsubota Ayumi、Saito Masayuki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 13243-13243

    • DOI

      10.1038/s41598-019-49754-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of brown adipose tissue in body temperature control during the early postnatal period in Syrian hamsters and mice2019

    • Author(s)
      Tsubota, A., Okamatsu-Ogura, Y., Bariuan, J.V., Mae, J., Matsuoka, S., Nio-Kobayashi, J., and Kimura, K.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 10 Pages: 1461-1467

    • DOI

      10.1292/jvms.19-0371

    • NAID

      130007732113

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice2019

    • Author(s)
      Shin W, Okamatsu-Ogura Y, Matsuoka S, Tsubota A, Kimura K.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 6 Pages: 799-807

    • DOI

      10.1292/jvms.19-0070

    • NAID

      130007660444

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interaction of nerve growth factor beta with adiponectin and SPARC oppositely modulates its biological activity2019

    • Author(s)
      Okura Y, Imao T, Murashima S, Shibata H, Kamikawa A, Okamatsu-Ogura Y, Saito M, Kimura K.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 20 Issue: 7 Pages: 1541-1541

    • DOI

      10.3390/ijms20071541

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation of bone marrow-derived cells toward thermogenic adipocytes in white adipose tissue induced by the β3 adrenergic stimulation.2019

    • Author(s)
      Yoneshiro T, Shin W, Machida K, Fukano K, Tsubota A, Chen Y, Yasui H, Inanami O, Okamatsu-Ogura Y, Kimura K.
    • Journal Title

      FASEB J

      Volume: 33 Issue: 4 Pages: 5196-5207

    • DOI

      10.1096/fj.201801757rr

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of Glucose Uptake and Uncoupling Protein 1 Activity in Adipose Tissue of Diabetic Mice upon β-Adrenergic Stimulation.2019

    • Author(s)
      Kubo N, Kawahara M, Okamatsu-Ogura Y, Miyazaki Y, Otsuka R, Fukuchi K.
    • Journal Title

      Mol Imaging Biol

      Volume: 21 Issue: 2 Pages: 249-256

    • DOI

      10.1007/s11307-018-1251-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] FSP27α inhibits autophagy-dependent lipid droplet breakdown in white adipocytes2019

    • Author(s)
      Nakajima S, Nishimoto Y, Tateya S, Iwahashi Y, Okamatsu-Ogura Y, Saito M, Ogawa W, Tamori Y.
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 6 Pages: 1419-1429

    • DOI

      10.1111/jdi.13050

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fasting-dependent Vascular Permeability Enhancement in Brown Adipose Tissues Evidenced by Using Carbon Nanotubes as Fluorescent Probes.2018

    • Author(s)
      Yudasaka M, Yomogida Y, Zhang M, Nakahara M, Kobayashi N, Tanaka T, Okamatsu-Ogura Y, Saeki K, Kataura H.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 14446-14446

    • DOI

      10.1038/s41598-018-32758-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance.2018

    • Author(s)
      Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A.
    • Journal Title

      Nutr Res

      Volume: 58 Pages: 17-25

    • DOI

      10.1016/j.nutres.2018.06.012

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膵臓の内分泌生理2018

    • Author(s)
      岡松優子
    • Journal Title

      SURGEON 129

      Volume: 22 Pages: 12-19

    • Related Report
      2018 Research-status Report
  • [Journal Article] Effect of ambient temperature on the proliferation of brown adipocyte progenitors and endothelial cells during postnatal BAT development in Syrian hamsters.2018

    • Author(s)
      Nagaya Kazuki、 Okamatsu-Ogura Yuko、 Nio-Kobayashi Junko、 Nakagiri Shohei、 Tsubota Ayumi、 Kimura, Kazuhiro
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 68 Issue: 1 Pages: 23-30

    • DOI

      10.1007/s12576-018-0606-8

    • NAID

      40021804614

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brown adipocytes postnatally arise through both differentiation from progenitors and conversion from white adipocytes in Syrian hamster2018

    • Author(s)
      Okamatsu-Ogura Yuko、Nio-Kobayashi Junko、Nagaya Kazuki、Tsubota Ayumi、Kimura Kazuhiro
    • Journal Title

      Journal of Applied Physiology

      Volume: 124 Issue: 1 Pages: 99-108

    • DOI

      10.1152/japplphysiol.00622.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Species-specific control of hepatocyte growth factor expression and production in adipocytes in a differentiation-dependent manner2018

    • Author(s)
      Yamaji D.、Soliman M.M.、Kamikawa A.、Ito T.、Ahmed M.M.、Okamatsu-Ogura Y.、Saito M.、Kimura K.
    • Journal Title

      Domestic Animal Endocrinology

      Volume: 62 Pages: 39-48

    • DOI

      10.1016/j.domaniend.2017.09.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of macrophages in depot-dependent browning of white adipose tissue2017

    • Author(s)
      Machida Ken、Okamatsu-Ogura Yuko、Shin Woongchul、Matsuoka Shinya、Tsubota Ayumi、Kimura Kazuhiro
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 68 Issue: 5 Pages: 601-608

    • DOI

      10.1007/s12576-017-0567-3

    • NAID

      40021645354

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell-cycle arrest in mature adipocytes impairs BAT development but not WAT browning, and reduces adaptive thermogenesis in mice2017

    • Author(s)
      Okamatsu-Ogura Yuko、Fukano Keigo、Tsubota Ayumi、Nio-Kobayashi Junko、Nakamura Kyoko、Morimatsu Masami、Sakaue Hiroshi、Saito Masayuki、Kimura Kazuhiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 6648-6648

    • DOI

      10.1038/s41598-017-07206-8

    • NAID

      120006482570

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retinoic acid modulates lipid accumulation glucose concentration-dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes.2017

    • Author(s)
      5.Abd Eldaim, M.A., Matsuka, S., Okamatsu-Ogura, Y., Kamikawa, A., Ahmed, M.M., Terao, A., Nakajima, K. and Kimura, K.
    • Journal Title

      Genes to Cells

      Volume: 印刷中 Issue: 6 Pages: 568-582

    • DOI

      10.1111/gtc.12498

    • NAID

      120006477490

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Progesterone dose-dependently modulates hepatocyte growth factor production in 3T3-L1 mouse preadipocytes2017

    • Author(s)
      Ito T, Yamaji D, Kamikawa A, Abd Eldaim MA, Okamatsu-Ogura Y, Terao A, Saito M, Kimura K
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: 8 Pages: 777-785

    • DOI

      10.1507/endocrj.EJ17-0097

    • NAID

      130006026350

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 褐色脂肪細胞によるエネルギー代謝調節2017

    • Author(s)
      岡松優子
    • Journal Title

      FOOD STYLE 21

      Volume: 21(8) Pages: 60-63

    • Related Report
      2017 Research-status Report
  • [Presentation] ハムスターにおける褐色脂肪組織の生後発達と恒温性の獲得2019

    • Author(s)
      岡松優子、坪田あゆみ、長屋一輝、前潤之介、小林純子、木村和弘
    • Organizer
      温熱生理研究会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 授乳期の高脂肪食給餌は、腸内細菌叢への影響を介して仔マウスにおけるベージュ脂肪細胞の発生を抑制する2019

    • Author(s)
      岡松優子、土生優妃、高橋菜摘、坪田あゆみ、園山慶、長屋一輝、木村和弘
    • Organizer
      第24回アディポサイエンス・シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] シリアンハムスターの褐色脂肪組織形成における骨形成タンパク質(BMP)受容体シグナル の役割2019

    • Author(s)
      前潤之介、岡松優子、長屋一輝、戸田知得、木村和弘
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 冬眠動物ハムスターにおける褐色脂肪組織の形成プログラミング機構2019

    • Author(s)
      岡松優子、長屋一輝、前潤之介、坪田あゆみ、小林純子、木村和弘
    • Organizer
      第162回日本獣医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] エネルギー代謝における褐色脂肪組織の役割と制御機構の解明2019

    • Author(s)
      岡松優子
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] シリアンハムスターにおいて褐色脂肪組織の生後発達を制御するシグナル経路の探索2018

    • Author(s)
      岡松優子
    • Organizer
      第2回冬眠休眠研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食餌性肥満モデルマウスにおいては血小板由来細胞増殖因子によるベージュ細胞前駆細胞の調節が抑制される2018

    • Author(s)
      シンウンチョル, 岡松優子, 木村和弘
    • Organizer
      第23回アディポサイエンス・シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 哺乳期マウスの腸内細菌叢の構成がベージュ脂肪細胞の出現に与える影響2018

    • Author(s)
      土生優妃, 岡松優子, 高橋菜摘, 戸田知得, 木村和弘
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 神経成長因子及び血管内皮増殖因子に及ぼすアディポネクチンの作用2018

    • Author(s)
      西村真理子, 中桐匠平, 松岡慎也, 戸田知得, 岡松優子, 木村和弘
    • Organizer
      第161回日本獣医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Brown adipose tissue thermogenesis-triggered organ crosstalk through exosomal microRNA-1222018

    • Author(s)
      Bariuan VJ, Okamatsu-Ogura Y, Tsubota A, Kimura K
    • Organizer
      The 6th Sapporo Summer Symposium for One Health
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血中エクソソームmiR-122-5pはヒト褐色脂肪活性を反映するバイオマーカーとなりうる2018

    • Author(s)
      岡松優子, 松下真美, 長屋一輝, 坪田あゆみ, 斉藤昌之
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 母マウスへの高脂肪食の給餌が乳仔期のベージュ脂肪細胞誘導に与える影響2018

    • Author(s)
      岡松優子
    • Organizer
      日本栄養・食糧学会北海道支部(第48回大会)・東北支部(第52回大会)合同支部大会公開シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] White adipocytes suppress brown adipocyte differentiation by secreting factors during the postnatal development of BAT in hamsters2018

    • Author(s)
      Okamatsu-Ogura Y, Nagaya K, Mae J, Tsubota A, Kimura K
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] シリアンハムスターにおける生後の褐色脂肪組織形成を制御する因子の解明2017

    • Author(s)
      長屋一輝、岡松優子、坪田あゆみ、戸田知得、木村和弘
    • Organizer
      第160回 日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 新生仔期のA/Jマウスにおけるベージュ脂肪細胞の誘導2017

    • Author(s)
      髙橋菜摘、岡松優子、坪田あゆみ、戸田知得、木村和弘
    • Organizer
      第160回 日本獣医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] シリアンハムスターにおける褐色脂肪組織の生後発達機構2017

    • Author(s)
      岡松優子
    • Organizer
      第1回冬眠休眠研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Adrenergic induction of beige adipocytes in white adipose tissue is attenuated with aging in mice2017

    • Author(s)
      Woongchul SHIN, Yuko OKAMATSU-OGURA, Ken Machida, Ayumi Tsubota, Junko Nio-Kobayashi, Kazuhiro KIMURA
    • Organizer
      24th European Congress on Obesity
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Remarks] 脂肪エネルギーを消費して熱を産生する褐色脂肪組織

    • URL

      https://www.vetmed.hokudai.ac.jp/organization/biochem/Research/pg96.html

    • Related Report
      2019 Annual Research Report

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Published: 2017-04-28   Modified: 2021-02-19  

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