Cellular and molecular basis for body temperature control system in hamster, a postnatal homeotherm animal model
| Project/Area Number |
17K08118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 褐色脂肪 / 体温調節 / UCP1 / ハムスター / 脂肪組織 / 熱産生 / 組織リモデリング / 冬眠動物 / 脂肪細胞 / 生後発達 / 脱共役タンパク質 / エネルギー代謝 |
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| Outline of Final Research Achievements |
The body temperature of a homeothermic animal is regulated by the balance between heat production and heat dissipation. In this study, the mechanism of the development of brown adipose tissue that is responsible for non-shivering thermogenesis was investigated using hamsters, which is a advantageous model to investigate the effect of internal and external factors on the tissue formation. It was revealed that the speed of brown adipose tissue formation was controlled by ambient temperature, but the formation itself was controlled by endogenous secretory factors in hamsters. These result may contribute to the understanding of the mechanism for the construction of a body temperature control system in mammals, and also provide new insights for applied research toward the development of therapeutic tool against metabolic syndrome.
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| Academic Significance and Societal Importance of the Research Achievements |
出生後に外温性から恒温性に転換する特殊なモデル動物であるハムスターにおける褐色脂肪組織の形成機構を理解することにより、哺乳動物に普遍的な体温制御システムの構築機構の理解に貢献できる。また、褐色脂肪組織は脂肪エネルギーを消費するため、肥満対策のターゲットとしても関心を集めている。本研究により見出された褐色脂肪組織形成を促進する因子は、褐色脂肪量を維持または増加させて太りにくい体質を獲得する新たなメタボリックシンドローム対策法の提示に向けた応用研究に活用できる。
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Role of brown adipose tissue in body temperature control during the early postnatal period in Syrian hamsters and mice2019
Author(s)
Tsubota, A., Okamatsu-Ogura, Y., Bariuan, J.V., Mae, J., Matsuoka, S., Nio-Kobayashi, J., and Kimura, K.
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Journal Title
Journal of Veterinary Medical Science
Volume: 81
Issue: 10
Pages: 1461-1467
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access
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[Journal Article] Melinjo (Gnetum gnemon L.) seed extract induces uncoupling protein 1 expression in brown fat and protects mice against diet-induced obesity, inflammation, and insulin resistance.2018
Author(s)
Yoneshiro T, Kaede R, Nagaya K, Saito M, Aoyama J, Elfeky M, Okamatsu-Ogura Y, Kimura K, Terao A.
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Journal Title
Nutr Res
Volume: 58
Pages: 17-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Retinoic acid modulates lipid accumulation glucose concentration-dependently through inverse regulation of SREBP-1 expression in 3T3L1 adipocytes.2017
Author(s)
5.Abd Eldaim, M.A., Matsuka, S., Okamatsu-Ogura, Y., Kamikawa, A., Ahmed, M.M., Terao, A., Nakajima, K. and Kimura, K.
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Journal Title
Genes to Cells
Volume: 印刷中
Issue: 6
Pages: 568-582
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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