| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify central and peripheral regulation on esophageal striated muscle motility in mammals. I characterized peristaltic motility using a novel in vivo method in rats. A balloon-tipped catheter was placed in the esophagus of a rat anesthetized with urethane to induce esophageal peristalsis. A nitric oxide synthase inhibitor abolished the induction of esophageal peristalsis, which suggests that nitric oxide plays essential roles in the induction of esophageal peristalsis. On the other hand, an isolated segment of the rat esophagus was placed in an organ bath and mechanical responses were recorded. Pharmacological and morphological studies indicated that purinergic receptors and potassium channels contribute to motor regulation of esophageal muscle motility peripherally. These findings provide novel insights into the regulatory mechanisms of esophageal striated muscle motility.
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