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Discovery of novel NPY-like RYamide peptide and analysis of appetite regulation mechanism

Research Project

Project/Area Number 17K08124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionUniversity of Miyazaki

Principal Investigator

Ida Takanori  宮崎大学, フロンティア科学総合研究センター, 准教授 (00381088)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生理活性ペプチド / オーファンGPCR / モデル生物 / オーファン受容体 / NPY / dRYamide / LURY-1 / 新規生理活性ペプチド / ニューロペプチドY / 摂食行動 / ショウジョウバエ / C/elegans
Outline of Final Research Achievements

The purpose of this study was to investigate the regulatory mechanism of feeding behavior required for animal life support using model organisms. In particular, the principal investigator discovered a peptide called dRYamide, LURY-1, which is similar to neuropeptide Y (NPY), which is important as a physiologically active peptide, so the research centered on its functional analysis. In parallel, we also searched for new bioactive peptides. As a result, they found that both dRYamide found in Drosophila and LURY-1 found in C. elegans cleverly regulate feeding behavior. In addition to the model organisms, the results were expected to be applied to animals important for agriculture and industry such as prawns and mosquitoes.

Academic Significance and Societal Importance of the Research Achievements

食欲は生命維持に必要なエネルギー摂取のためのもっとも基本的な生命活動であり、本能行動の中でも特に重要である。その調節メカニズムを解明しコントロールすることが出来れば、人での創薬はもちろん、家畜、養殖魚類や有用昆虫の効率的育成、害虫の駆除などに応用でき非常に意義深い。また、摂食コントロールの破綻は生活習慣病など様々な疾病に結びつき、社会的に重要な課題である。dRYamide、LURY-1はヒトの摂食コントロールに関わるニューロペプチドYファミリーと類縁関係にあり、本研究ははショウジョウバエや線虫に限らず、ヒトも含めたすべての動物に共通な摂食制御のしくみの理解に役立つことが期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (32 results)

All 2020 2019 2018 2017 Other

All Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 10 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (19 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Evaluation of 17β-hydroxysteroid dehydrogenase activity using androgen receptor-mediated transactivation2020

    • Author(s)
      Yazawa Takashi、Imamichi Yoshitaka、Uwada Junsuke、Sekiguchi Toshio、Mikami Daisuke、Kitano Takeshi、Ida Takanori、Sato Takahiro、Nemoto Takahiro、Nagata Sayaka、Islam Khan Md. Rafiqul、Takahashi Satoru、Ushikubi Fumitaka、Suzuki Nobuo、Umezawa Akihiro、Taniguchi Takanobu
    • Journal Title

      The Journal of Steroid Biochemistry and Molecular Biology

      Volume: 196 Pages: 105493-105493

    • DOI

      10.1016/j.jsbmb.2019.105493

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppressive effect of ghrelin on nicotine-induced clock gene expression in the mouse pancreas2020

    • Author(s)
      Sato Takahiro、Oishi Kanae、Ida Takanori、Kojima Masayasu
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 1 Pages: 73-80

    • DOI

      10.1507/endocrj.EJ19-0169

    • NAID

      130007790946

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new action of peptide hormones for survival in a low-nutrient environment2019

    • Author(s)
      Sato Takahiro、Nemoto Takahiro、Hasegawa Kazuya、Ida Takanori、Kojima Masayasu
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 11 Pages: 943-952

    • DOI

      10.1507/endocrj.EJ19-0274

    • NAID

      130007751663

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 消化管関連ペプチドが拓く恒常性フロンティア2019

    • Author(s)
      佐藤貴弘、井田隆徳、関口俊男、中町智哉、児島将康
    • Journal Title

      実験医学

      Volume: 37 Pages: 1-8

    • Related Report
      2019 Annual Research Report
  • [Journal Article] The CCHamide1 Neuropeptide Expressed in the Anterior Dorsal Neuron 1 Conveys a Circadian Signal to the Ventral Lateral Neurons in Drosophila melanogaster2018

    • Author(s)
      Fujiwara Yuri、Hermann-Luibl Christiane、Katsura Maki、Sekiguchi Manabu、Ida Takanori、Helfrich-F?rster Charlotte、Yoshii Taishi
    • Journal Title

      Frontiers in Physiology

      Volume: 9 Pages: 1-15

    • DOI

      10.3389/fphys.2018.01276

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes2018

    • Author(s)
      Akieda-Asai S, Ida T, Miyazato M, Kangawa K, Date Y
    • Journal Title

      Peptides

      Volume: 99 Pages: 14-19

    • DOI

      10.1016/j.peptides.2017.10.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice2018

    • Author(s)
      Teranishi Hitoshi、Hayashi Masafumi、Higa Ryoko、Mori Kenji、Miyazawa Takashi、Hino Jun、Amano Yuichiro、Tozawa Ryuichi、Ida Takanori、Hanada Toshikatsu、Miyazato Mikiya、Hanada Reiko、Kangawa Kenji、Nakao Kazuwa
    • Journal Title

      Peptides

      Volume: 99 Pages: 134-141

    • DOI

      10.1016/j.peptides.2017.09.011

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Luqin-like RYamide peptides regulate food-evoked responses in C. elegans2017

    • Author(s)
      Ohno H, Yoshida M, Sato T, Kato J, Miyazato M, Kojima M, Ida T, Iino Y
    • Journal Title

      Elife

      Volume: 6. pii Pages: 1-23

    • DOI

      10.7554/elife.28877

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release2017

    • Author(s)
      Mori Kenji、Ida Takanori、Fudetani Mami、Mori Miwa、Kaiya Hiroyuki、Hino Jun、Nakahara Keiko、Murakami Noboru、Miyazato Mikiya、Kangawa Kenji
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-017-10319-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and immunoregulatory function of neuromedin U (NMU) in the Japanese pufferfish Takifugu rubripes2017

    • Author(s)
      Tomoya Kono, Takanori Ida, Natsumi Kawahara, Fumiya Watanabe, Gouranga Biswas, Takahiro Sato, Kenji Mori, Mikiya Miyazato
    • Journal Title

      Developmental and Comparative Immunology

      Volume: in press Pages: 246-256

    • DOI

      10.1016/j.dci.2017.03.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Purification and characterization of bioactive peptides RYamide and CCHamide in the kuruma shrimp Marsupenaeus japonicus2017

    • Author(s)
      Mekata T, Kono T, Satoh J, Yoshida M, Mori K, Sato T, Miyazato M, Ida T*
    • Journal Title

      Gen Comp Endocrinol

      Volume: 246 Pages: 321-330

    • DOI

      10.1016/j.ygcen.2017.01.008

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 新規生理活性ペプチドdRYamide, LURY-1の発見2019

    • Author(s)
      井田隆徳
    • Organizer
      第66回日本実験動物学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 宮崎から世界へ羽ばたくペプチドホルモン研究2019

    • Author(s)
      井田隆徳
    • Organizer
      日本プロテオーム学会2019大会第70回日本電気泳動学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 漢方からのペプチド探索2019

    • Author(s)
      井田隆徳
    • Organizer
      第10回ペプチドホルモン研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] モデル生物における新規生理活性ペプチドの発見と応用2019

    • Author(s)
      井田隆徳
    • Organizer
      第43回 蛋白質と酵素の構造と機能に関する九州シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] モデル生物における新規生理活性ペプチドの発見と応用2019

    • Author(s)
      井田隆徳
    • Organizer
      第19回日本内分泌学会九州支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多様な動物種を用いた生理活性ペプチドの探索2019

    • Author(s)
      井田隆徳
    • Organizer
      日本動物学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 様々な手法を用いた新規生理活性ペプチドの探索2019

    • Author(s)
      井田隆徳
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ニューロメジンU、ニューロメジンSとそれらの前駆体関連ペプチドのプロラクチン分泌への相反的作用について2018

    • Author(s)
      村上 昇、森 健二、宮里幹也、中原桂子、大谷 瞳、筆谷麻未、井田隆徳、丸山圭介、寒川賢治
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 新規生理活性ペプチドdRYamide, LURY-1の発見2018

    • Author(s)
      井田隆徳、大野速雄、吉田守克、佐藤貴弘、宮里幹也、児島将康、飯野雄一
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規生理活性ペプチドNURPの発見とそのプロラクチン分泌促進活性2018

    • Author(s)
      森 健二、井田隆徳、中原桂子、村上昇、宮里 幹也、寒川 賢治
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] オーファン受容体に対する糖鎖ペプチドの探索2018

    • Author(s)
      井田隆徳
    • Organizer
      第9回ペプチド・ホルモン研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 第3回ペプチド・ホルモン研究会シンポジウム2018

    • Author(s)
      井田隆徳
    • Organizer
      第89回日本動物学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Identification of the novel bioactive peptides using model animal2018

    • Author(s)
      井田隆徳
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Identification of the bioactive peptides from model animal2017

    • Author(s)
      Takanori Ida
    • Organizer
      International meeting on non-mammalian models in biomedical research: Current status and future perspectives
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] CeRYamides, members of the conserved RYamide peptide family, mediate food responses after fasting in C. elegans2017

    • Author(s)
      Hayao Ohno, Morikatsu Yoshida, Takahiro Sato, Johji Kato, Mikiya Miyazato, Masayasu Kojima, Takanori Ida & Yuichi Iino
    • Organizer
      16th IGAKUKEN International Symposium on Functions and mechanisms of neuromodulation
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 異分野融合:新規生理活性ペプチドの探索2017

    • Author(s)
      井田隆徳
    • Organizer
      第8回 ペプチド・ホルモン研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] プロラクチン分泌促進活性を有する新規生理活性ペプチドneuromedin U precursor-related peptideの発見2017

    • Author(s)
      森 健二、井田隆徳、中原桂子、村上昇、宮里 幹也、寒川 賢治
    • Organizer
      第40回日本分子生物学会年会(2017年度生命科学系学会合同年次大会(ConBio2017))
    • Related Report
      2017 Research-status Report
  • [Presentation] まだ見ぬ生理活性ペプチドを求めて2017

    • Author(s)
      井田隆徳
    • Organizer
      第40回日本分子生物学会年会(2017年度生命科学系学会合同年次大会(ConBio2017))
    • Related Report
      2017 Research-status Report
  • [Presentation] RYamideペプチドの新展開2017

    • Author(s)
      井田隆徳
    • Organizer
      第14回GPCR研究会
    • Related Report
      2017 Research-status Report
  • [Remarks] 井田研究室

    • URL

      http://www.cc.miyazaki-u.ac.jp/a0d203u/

    • Related Report
      2019 Annual Research Report 2017 Research-status Report
  • [Remarks] 井田研究室

    • URL

      https://www.cc.miyazaki-u.ac.jp/a0d203u/

    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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