| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Accumulation of neutrophils and macrophages is a critical event in the pathogenesis of lung inflammation. Myeloperoxidase (MPO) and phagocyte NADPH oxidase (NOX2) contribute to microbial killing. This study aimed to evaluate the effect of MPO deficiency and NOX2 deficiency on lung inflammation induced by zymosan and nonviable Candida. Mice deficient in these enzymes showed more severe pneumonia than wild-type, which exhibited higher lung concentrations of proinflammatory cytokines such as MIP-2 and KC. In vitro, dectin-1 contributed to the production of those cytokines, which was associated with an upregulation of ERK pathway. We also found that NOX2 deficiency exhibits severe thymic atrophy and resulting lymphopenia concomitant with enhanced neutrophilic inflammation in a zymosan-induced systemic inflammation model.
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