• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of endometrial regeneration mechanism by mesenchymal epithelial conversion of bovine endometrial stromal SP cells

Research Project

Project/Area Number 17K08141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionNagoya University (2018-2019)
National Agriculture and Food Research Organization (2017)

Principal Investigator

Matsuyama Shuichi  名古屋大学, 生命農学研究科, 准教授 (50455317)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords幹細胞 / 子宮 / 牛
Outline of Final Research Achievements

In this study, the RNA-seq analysis of side population (SP) cell identified in bovine endometrium revealed that SP cells have stem/progenitor cell-like properties, and some of them might be derived from bone marrow. The ratio of SP cells in endometrial cells were low immediately after parturition and then gradually increased, suggesting that SP cells are differentiated and proliferated into endometrial cells after parturition. Besides, the ratio of endometrial SP cells in low fertility cows with a high number of calving was similar to that in normal fertility cows with a low number of calving. From this result, it is possible that the ratio of SP cells is not affected by parity, and the number of SP cells is unlikely to affect fertility in cows.

Academic Significance and Societal Importance of the Research Achievements

本研究では、牛の子宮に組織幹細胞の性質を持った細胞が存在することが明らかにされ、分娩後の子宮修復に関与する可能性が示されました。牛では分娩後の受胎率が低いことが知られています。この受胎率の低下は分娩後の子宮修復の不具合が一因となっている可能性がありますが、本研究の成果は、子宮の組織幹細胞を利用することで子宮修復の不具合を改善させるといった、これまでにないアプローチでの受胎率向上技術の開発に寄与することが期待されます。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (2 results)

All 2019 2018

All Presentation (2 results)

  • [Presentation] ウシ子宮内膜side population細胞における幹細胞マーカーの発現解析2019

    • Author(s)
      舘林亮輝、中村翔、美辺詩織、古澤軌、阿部良哉、森田康広、大蔵聡、木村康二、松山秀一
    • Organizer
      第112回日本繁殖生物学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウシ子宮内膜細胞のSide population解析2018

    • Author(s)
      館林亮輝、阿部良哉、中村翔、美辺詩織、木村康二、森田康広、大蔵聡、松山秀一
    • Organizer
      平成30年度 愛知県農学系4機関による研究交流会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi