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The Mechanisms of segment specific response to hormones in pupal metamorphosis and cell death

Research Project

Project/Area Number 17K08147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Insect science
Research InstitutionHirosaki University

Principal Investigator

Kaneko Yu  弘前大学, 農学生命科学部, 准教授 (90633610)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords体節特異性 / 蛹変態 / 幼若ホルモン / カイコ / 変態 / 細胞死 / コミットメント
Outline of Final Research Achievements

Insect molting and metamorphosis are controlled mainly by two hormones secreted into hemolymph. One is ecdysteroids that induce molting, and the other is juvenile hormones (JH) that have the status quo action. Each cell shows unique response to the hormones. Because of open circulatory system in insects, all cells are exposed to the same concentration of the hormones at the same time. Therefore, we focused on the cell-specific response to JH and attempted to elucidate this mechanism. As a result, we found that various genes showed a response to hormones peculiar to the location of cells, and that some homeotic genes might be involved in the regulation of the response.

Academic Significance and Societal Importance of the Research Achievements

個々の組織におけるホルモン応答機構についての議論はされてきたものの、これまで開放血管系における体節特異的なホルモン応答の分子機構については全く理解が進んでいない。その結果、個体発育におけるホルモン応答機構の理解は十分には行われていなかった。本研究結果を基に今後理解が深まると考えられる。また本研究によるホルモンの体節特異的作用を導く因子の同定および作用機構の解明は、組織特異的に作用させることでより効率的な殺虫剤の開発に貢献するともに、細胞死研究も対象とすることから殺虫剤の直接的な標的の探索への応用も期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (9 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Int'l Joint Research] Chiang Mai University(タイ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Chiang Mai University(タイ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Diapause hormone directly stimulates the prothoracic glands of diapause larvae under juvenile hormone regulation in the bamboo borer, Omphisa fuscidentalis Hampson2019

    • Author(s)
      Suang Suphawan、Hiruma Kiyoshi、Kaneko Yu、Manaboon Manaporn
    • Journal Title

      Archives of Insect Biochemistry and Physiology

      Volume: 102 Issue: 2 Pages: 1-13

    • DOI

      10.1002/arch.21603

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cloning and Developmental Expression of Methoprene-tolerant (Met) in Diapausing Larvae of the Bamboo Borer, Omphisa fuscidentalis Hampson.2018

    • Author(s)
      Suang, S., T. Singtripop, Chantawannakul, K. Hiruma, Y. Kaneko, M. Manaboon
    • Journal Title

      Chiang Mai J. Sci.

      Volume: 45 Pages: 2303-2311

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Verson’s glandの蛹コミットメントにおける4E-BPとS6kinaseの機能解析2020

    • Author(s)
      三上翔平, 山下和志, 金児雄
    • Organizer
      日本蚕糸学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコ終齢致死変異体における遺伝子発現変動解析2020

    • Author(s)
      大森裕介, 髙橋仁輝, 金児雄, 藤井告, 伴野豊
    • Organizer
      日本蚕糸学会第90回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Target of Rapamycin (TOR) によるVerson’s gland細胞死コミットメントの誘導2018

    • Author(s)
      金児雄・比留間潔
    • Organizer
      蚕糸・昆虫機能利用学術講演会
    • Related Report
      2017 Research-status Report
  • [Presentation] Target of Rapamycin (TOR) induces the cell death commitment of Verson’s gland of Bombyx mori.2017

    • Author(s)
      Kaneko, Y., Hiruma, K.
    • Organizer
      3rd International Insect Hormone (21th Ecdysone) Workshop
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] カイコの実験単 ~カイコで生命科学をまるごと理解~2019

    • Author(s)
      金児 雄, 塩見 邦博, 天竺桂 弘子, 他56名
    • Total Pages
      304
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      9784860435981
    • Related Report
      2018 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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