| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
In this study, several functional recognition molecules for 8-oxidized guanosine derivatives produced by oxidative stresses in biological systems have been developed. Actually, capture molecules or fluorescence probes targeted toward 8-nitroguanosine, 8-thioguanosine and 8-oxoguanosine have been designed, synthesized and evaluated. These functional molecules exhibited specific capture reactivity or fluorescence response for target nucleosides in the biomimetic condition. The functional molecules developed in this study are expected as specific and versatile probes for 8-oxidized guanosine derivatives.
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