| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Development of new synthetic reactions triggered by nitrogen-oxygen bond cleavage is attempted. We found several new transformations represented by (i) the nucleophilic γ-phenylation and γ-alkylation of α,β-unsaturated amides, and (ii) α-phenylation of ketones with triphenylaluminium in the presence of (+)-benzopyranoisoxazolidine. These new methods would be a useful synthetic tool for the preparation of optically active drug candidates and biologically active molecules.
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