| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We have developed a catalytic reaction with the novel organoboronic acid which enhances the nucleophilicity of the specific hydroxy group of vicinal cis-diol in glycopyranoside. This method enables regioselective acylation and carbonate formation of an equatorially oriented hydroxy group in vicinal cis-diol. Aromatic acyl chlorides, alkyl acyl chlorides, and unsaturated acyl chlorides can be used as an acylating agent, and the applicable amount of catalyst is very small from 0.05 mol% to 1 mol%. Therefore, we succeeded in developing a useful organic boronic acid catalyst for practical use.
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