| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Organic Superbase-catalyzed intramolecular hydroamination of aminoalkenes was examined. Phosphazene t-Bu P4 base effectively catalyzed the hydroamination to give cyclized product in good yield. High basicity of phosphazene catalyst was essential for this reaction, and normal organic bases did not catalyze the reaction. Although this reaction required high reaction temperature and long reaction time, various aminoalkenes were applicable. We also found that microwave irradiation dramatically shortened the reaction time. Phosphazene catalyst system was also applicable to an intramolecular hydroalkoxylation of hydroxyalkenes.
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