Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Final Research Achievements |
Nitrogen containing organic compounds are frequently found in biologically active compounds and are also important as synthetic intermediates for functional materials such as pharmaceuticals. In this study, development of novel organozinc species containing a nitrogen functional group and utilization of such species for the synthesis of nitrogen containing organic compounds have been examined. Accordingly, it was found that an NHC-copper salt could catalyze carbozincation of allenamides with dialkylzinc reagents in regioselective manner to form vinylzinc species. Furthermore, the addition of a catalytic amount of paraformaldehyde could greatly accelerated the present carbozincation process. The generated vinylzinc species could be used for various carbon-carbon formation reactions such as palladium-catalyzed cross-coupling reactions.
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