| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In transcriptional regulation by nuclear receptors, transcriptional cofactors bind to the receptor in a ligand-dependent manner. In this study, we analyzed the effect of agonists on the selection of transcriptional cofactor-derived peptides by a heterodimer consisting of the nuclear receptor PPARγ/RXRα, which is important for metabolic regulation. We found the existence of a dynamic equilibrium in solution among multiple states where each receptor has a different binding peptide. Ligand binding to one of the receptors regulates cofactor binding to the other receptor, indicating a dynamic allosteric communication between receptors.
|
