| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The purpose of this study was to design and develop drugs for the treatment of influenza virus infection. We first revealed the three-dimensional structures of eight segmented single-stranded influenza virus genomic RNAs (vRNA) and their counter-stranded RNAs (cRNA) using X-ray crystallography. The obtained structural snapshots were then connected to create movies to observe the dynamic structural changes of vRNA and cRNA. Furthermore, we analyzed the binding mode of aminoglycosides to vRNA, cRNA and the ribosomal RNA switch. We designed drug candidates that bind to vRNA and cRNA based on the three-dimensional structural information obtained in this study.
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