| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
A large quantity of sulfate and sulfide are reportedly associated with on-set and return of ulcerative colitis. In this study, we found that sulfate and sulfite levels in colonic tissue were increased and sulfite radical was produced prior to occurrence of colitis using mice with experimental colitis. And, we revealed that colonic ascorbic acid and glutathione could be associated with the decomposition of sulfite radical. Furthermore, the involvement of sulfatase and 3'-phosphoadenosine-5'-phosphosulfate synthase with the sulfite radical production was suggested.
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