The role of IL-17A-induced mRNA stabilization in immune-related diseases
| Project/Area Number |
17K08263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IL-17 / サイトカイン / シグナル伝達 / mRNA安定性制御 / 炎症 / mRNA安定化 / 免疫関連疾患 |
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| Outline of Final Research Achievements |
IL-17 is an inflammatory cytokine, which is important in the pathogenesis of autoimmune diseases. In this study we aimed to elucidate the mechanism of the IL-17 action.We have identified the molecules that mediate the signal transduction process in IL-17-induced mRNA stabilization. Further, we have found that dimethyl fumarate and TBK1 inhibitor can suppress the signal transduction leading to mRNA stabilization.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、サイトカインIL-17がmRNA安定化反応を介して炎症を促進する際の分子機構の一端が解明された。また、IL-17によって起こるmRNA安定化反応を抑制できる低分子化合物が同定された。このような効果をもつ化合物はIL-17に惹起される炎症を伴う免疫疾患の抑制に役立てられる可能性があり、また、研究のツールとして用いることで分子機構のさらなる詳細を解明するための後続研究に利用できる。
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases.2017
Author(s)
Matsumoto N, Kon S, Nakatsuru T, Miyashita T, Inui K, Saitoh K, Kitai Y, Muromoto R, Kashiwakura JI, Uede T, Matsuda T.
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Journal Title
J Immunol.
Volume: 199
Issue: 1
Pages: 82-90
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.2017
Author(s)
Kitai Y, Iwakami M, Saitoh K, Togi S, Isayama S, Sekine Y, Muromoto R, Kashiwakura JI, Yoshimura A, Oritani K, Matsuda T
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Journal Title
J Biol Chem
Volume: 292(47)
Issue: 47
Pages: 19392-19399
DOI
NAID
Related Report
Peer Reviewed / Open Access
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