| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
G-protein-coupled receptors (GPCRs) represent the largest class of human membrane proteins. They are also regarded as important targets for drug development. GPCRs mediate signal information from external stimuli such as hormones and drugs to intracellular responses. Characterizing signal profiling of GPCRs is critical for understanding not only GPCR biology, but also GPCR-targeting drugs. In this project, we developed various methods to assess G-protein-coupling profiles of GPCRs and characterized more than 100 GPCR signaling. Through bioinformatics analysis, this experimental database enabled us to develop an algorithm to score signaling profile based on a given GPCR sequence. These achievement will contribute to development of GPCR-targeting drugs including a signal-biased ligand, which is expected to serve as a safe drug with a reduced side effect.
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