The regulatory mechanism of Reelin and its importance in neuropsychiatric disorders
| Project/Area Number |
17K08281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
Kohno Takao 名古屋市立大学, 医薬学総合研究院(薬学), 講師 (70581742)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 樹状突起 / 神経細胞移動 / 脳 / プロテオリシス / 大脳皮質 / プロテアーゼ / リーリン / 脳・神経 / 細胞・組織 / 脳神経疾患 |
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| Outline of Final Research Achievements |
Reelin is an essential molecule for the formation of cerebral layered structures, and its hypofunction is involved in the onset of Alzheimer's disease and schizophrenia. In this study, we identified a novel membrane protein that binds to Reelin and functions as a co-receptor for canonical Reelin receptors. Moreover, we found that the activity of Reelin is regulated by multiple proteases and its suppression may be a therapeutic target for Alzheimer's disease.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、脳の形成や機能制御に重要な役割をもつリーリンに着目して研究をおこない。リーリンの新たな機能制御機構とその脳における重要性が明らかになった。本研究で得られた知見は、精神神経疾患の治療法開発につながると期待される。
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia.2018
Author(s)
Sobue A, Kushima I, Nagai T, Shan W, Kohno T, Aleksic B, Aoyama Y, Mori D, Arioka Y, Kawano N, Yamamoto M, Hattori M, Nabeshima T, Yamada K, Ozaki N.
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Journal Title
Sci Rep.
Volume: 8
Issue: 1
Pages: 13046-13046
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Reelin deficiency leads to aberrant lipid composition in mouse brain.2018
Author(s)
Mizukami T, Ikeda K, Shimanaka Y, Korogi K, Zhou C, Takase H, Tsuiji H, Kono N, Kohno T, Arai H, Arita M, Hattori M.
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Journal Title
Biochem Biophys Res Commun
Volume: 505
Issue: 1
Pages: 81-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017
Author(s)
Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M
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Journal Title
J Neurosci
Volume: 37
Issue: 12
Pages: 3181-3191
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin2017
Author(s)
Himari Ogino, Arisa Hisanaga, Takao Kohno, Eisuke Okugawa, Tomoha Ohsima, Yuta Kondo, Kyoko Okumura, Takana Kamei, Tempei Sato, Hiroshi Asahara, Hitomi Tsuiji, Masaki Fukata, Mitsuharu Hattori
Organizer
第40回 日本神経科学大会
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[Presentation] To clarify how Reelin affects the lipid compositions of neurons2017
Author(s)
Katsunari Korogi, Tomoharu Mizukami, Chunyu Zhou, Takao Kohno, Fumiyoshi Yamazaki, Katsuya Kabashima, Yuta Shimanaka, Kazutaka Ikeda, Hiroyuki Arai, Makoto Arita, Mitsutoshi Setou, Mitsuharu Hattori
Organizer
ConBio2017
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