| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
To develop new medicine for insulin resistance, it is important to clarify the molecular mechanisms of regulation of the insulin signaling pathway and adipocyte differentiation. In this study, we demonstrated that activation of KCNMA1 channels is required for the regulation of insulin signaling in mature adipocytes. Furthermore, we revealed that the expression of KCa3.1 was upregulated in WAT of mice fad a high fat diet, and was quickly elevated after induction of adipocyte differentiation. In addition, knockdown and overexpression experiments showed that KCa3.1 negatively regulates adipocyte differentiation. Further analyses of KCNMA1 and KCa3.1 will help to understand the molecular mechanisms of insulin signaling pathway and adipocyte differentiation.
|
