| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The heart-specific GPx4 knockout mouse can survive by the vitamin E supplementation diet, but lipid peroxidation-dependent novel cell death is induced in cardiomyocytes by decrease of vitamin E in heart after change to low vitamin E containing diet, resulting in cardio sudden death. We found antibiotic cefoperazone(CPZ) as the non-antioxidant compound which can suppress this lipid peroxidation-dependent heart failure by drinking, but not intraperitoneal injection. Administration of antibiotic CPZ could not rescue lipid peroxidation dependent cardio sudden death in germ free mice. Next generation sequencer and bacteria transplantation experiment revealed that antibiotic CPZ resistant intestinal bacteria could suppress lipid peroxidation dependent cardio sudden death in heart-specific GPx4 knockout mouse.
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