| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The present study suggested that LRP1 in neurons was cleaved after cerebral infarction and might lead to brain dysfunction. In addition, it was revealed that this LRP1 cleavage caused a marked increase in the intracellular domain and a decrease in the extracellular domain, and the intracellular domain of LRP1 was localized in the perinuclear region after NMDA treatment. In addition to clarifying the role of furin involved in this cleavage, we also elucidated that furin inhibitor dose-dependently prevented neuronal injury induced by NMDA treatment. These useful findings would contribute to the development of therapeutic agents for cerebral infarction.
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