| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the regulation mechanism of skeletal muscle function by the biological clock system, and to present the molecular basis of the time drug treatment of metabolic syndrome based on the knowledge. In order to achieve this goal, we generated mice with a skeletal muscle-specific deletion of BMAL1, a key transcription factor in biological clock control (M-BMAL1KO mice), and analyzed the characteristics of their energy metabolism from biochemical and pathological viewpoints. The results showed that BMAL1 regulates calcium and oxygen uptake and through this regulates fatty acid combustion and subsequent energy metabolism in skeletal muscle.
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