| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Recent studies about the concept of immunogenic cell death suggested that it would be possible to prepare effective vaccine by live tumor cells but not formalin fixed- or frozen-tumor tissue. In this project, we established the method to prepare a novel cell based vaccine using original designed adjuvant “lipopeptide adhering to cell surface by a charge-dependent manner”.
On the other hand, we succeeded in identifying some candidate molecules as cancer vaccine-related immunogenic factors in vaccine cell line. We are planning to apply these findings for the next cancer vaccine strategy as a novel perspective of drug discovery.
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