| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In the present study, we mainly focused on the role of p53 in the regulation of podocyte in in vitro and in vivo models. By in vitro analysis, we proved that treatment of murine podocyte MPC-5 cells with p53 activator Nutlin-3alpha significantly increases podocyte-functional genes' expression. On the other hand, p53 deficient in the anti-Nephtin-induced nephropathy model did not affect kidney phenotypes. Overall, p53 is partly involved in nephropathy phenotype through podocye, but in vivo relevances need to be clarified in the future study.
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