| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We hypothesized that "dematuration" functional changes cooperate with neurogenesis in the hippocampus and contribute to the therapeutic effect of depression. In this study, we aimed to identify targets involved in hippocampal function regulation and depression treatment.
1)We found that ECS suppressed the maturation process while promoting the survival and differentiation of newborn nerves. 2)Using a treatment-resistant depression model, we searched for factors that are resistant to depression treatment. In the treatment-resistant depression hippocampus, the ECS-induced neurotrophic factor BDNF expression was detected. 3)To explore the signaling of antidepressant treatment in the hippocampus, we examined the contribution of neurotrophic factor NT3 on the hippocampal neurogenesis. We suggested that NT-3 knockdown in the dentate gyrus promoted neuronal differentiation.
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