| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
A study was conducted to clarify the involvement of GRK2 inactivation and endothelial dysfunction in the diabetes mellitus. It was revealed that suppression of GRK2 activity affected vascular endothelial dysfunction by targeting the Akt/eNOS signaling pathway. Furthermore, the suppression of hepatic GRK2 dramatically improved systemic glucose homeostasis and insulin sensitivity, and these data suggested that the rapidly normalized glucose homeostasis as well as insulin sensitivity played an important role in modulating endothelial function. From the above, it is suggested that GRK2 inactivation may contribute to the prevention of the onset of the diabetic endothelial dysfunction.
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