Development of novel therapeutic agents for Alzheimer's disease based on analysis of neuroprotective signals and regulation of tau phosphorylation
| Project/Area Number |
17K08323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Doshisha Women's College of Liberal Arts |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
久米 利明 富山大学, 学術研究部薬学・和漢系, 教授 (10303843)
宮坂 知宏 同志社大学, 生命医科学部, 准教授 (90342857)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Project Status |
Completed (Fiscal Year 2019)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | アルツハイマー型認知症 / タウ / アルツハイマー病 / 薬学 / 薬理学 / 脳・神経 |
|---|
| Outline of Final Research Achievements |
Tau hyperphosphorylation is one hallmark of Alzheimer’s disease. Here, we investigated the effects of donepezil on tau hyperphosphorylation induced by hypothermia in vivo and in vitro. The phosphorylation levels of tau were significantly increased under hypothermia treatment. Pretreatment with donepezil prevented hypothermia-induced tau phosphorylation induced by hypothermia. These results suggest that donepezil prevents hypothermia--induced tau hyperphosphorylation in vivo and in vitro.
|
| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病治療薬の神経保護作用の作用点は未だにわかっておらず、そこに至る作用機序についても不明な点が多い。本研究成果の学術的意義は、これらを明らかにすることで新たな作用点を有する新規アルツハイマー病治療薬の開発に繋がる重要な基礎的情報を得ることである。本研究の社会的意義として、高齢化社会における国民の健全な老後生活に大きく貢献することができると予想される。
|
Report
(4 results)
Research Products
(10 results)
