Elucidation of the mechanisms by which microglia enhance the functional maturation of blood brain barrier
Project/Area Number |
17K08330
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pharmacology in pharmacy
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Research Institution | National Institute of Health Sciences |
Principal Investigator |
Sato Kaoru 国立医薬品食品衛生研究所, 薬理部, 室長 (10311391)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | ミクログリア / 血液脳関門 / サイトカイン / ケモカイン / 発達 / BBB / 生後発達 |
Outline of Final Research Achievements |
We clarified that the roles of microglia in both of healthy BBB and pathological BBB. Of note, we identified two cytokines are essential to the effects of microglia. These findings will lead to the new therapeutic targets in the CNS diseases associated with BBB breakdown.
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Academic Significance and Societal Importance of the Research Achievements |
ミクログリアによる正常時の BBB バリア機能調節機構、それに関わるサイトカイン・ケモカインを明らかとすることで、炎症をともなう中枢神経疾患における BBB機能破綻に対するそれらサイトカイン・ケモカインの治療応用性について明らかとした。以上の知見は中枢神経系への薬物送達のための重要な情報となることも期待される。
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Hyaluronan synthesis supports glutamate transporter activity2019
Author(s)
Hayashi MK, Nishioka T, Shimizu H, Takahashi K, Kakegawa W, Mikami T, Hirayama Y, Koizumi S, Yoshida S, Yuzaki M, Tammi M, Sekino Y, Kaibuchi K, Shigemoto-Mogami Y, Yasui M, Sato K.
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Journal Title
Journal of Neurochemistry
Volume: 150
Issue: 3
Pages: 249-263
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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