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Evidence of medicinal properties and efficacy of Southeast Asian medicinal plants

Research Project

Project/Area Number 17K08333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionOsaka Ohtani University (2018-2019)
University of Toyama (2017)

Principal Investigator

Ito Takuya  大阪大谷大学, 薬学部, 教授 (90517484)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords東南アジア / 薬用植物 / 抗インフルエンザ活性 / 抗菌活性 / 伝統医学 / 抗ウイルス活性 / 感染症 / ミャンマー / 振興再興完成症 / 抗ウイルス
Outline of Final Research Achievements

In Southeast Asia, a huge number of species live, scientific research on biological activity and active ingredients of natural resources has not been conducted. Recently, in order to verify the effectiveness of the medicinal plants used in traditional medicine of Southeast Asia, phytochemical studies have been carried out. As a result, strong anti-influenza activity was observed in five kinds of medicinal plant extracts such as Jatropha multifida (Euphorbiaceae) and Gentiana Kurroo (Gentianaceae).New melanin inhibitors were also found in Premna integrifolia corrected in Myanmar.

Academic Significance and Societal Importance of the Research Achievements

東南アジアをはじめ世界各地では現在でも伝統医学が治療に用いられている。近年、様々な伝統医学が世界保健機構の認定を受けて、西洋医学の代替医療として注目されている。伝統医学はその地域に根ざした文化・生活・習慣を背景に現在でも伝承されている地域遺産であり、今後も継承し続ける必要がある。しかしながら、治療効果の科学的なエビデンスは欠如しており、経験に基づいた治療が行われているのが現状である。このことから科学的根拠に基づいた伝統医学への転換するためにも本研究を遂行する意味がある。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 Other

All Int'l Joint Research (2 results) Journal Article (17 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 17 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] University of Yangon(ミャンマー)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Indonesian Institute of Sciences(インドネシア)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Viral protein R inhibitors from Swertia chirata of Myanmar2019

    • Author(s)
      Woo, S., Win, N.N., Oo, W.M.N., Ngwe, H., Ito, T., Abe, I., Morita, H.
    • Journal Title

      J. Biosci. Bioeng.

      Volume: 128 Issue: 4 Pages: 445-449

    • DOI

      10.1016/j.jbiosc.2019.04.006

    • NAID

      40022037152

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dinorcassane Diterpenoid from Boesenbergia rotunda Rhizomes Collected in Lower Myanmar2019

    • Author(s)
      Win Nwet Nwet、Kyaw May Mon、Prema、Ngwe Hla、Ito Takuya、Asakawa Yoshinori、Okamoto Yasuko、Tanaka Masami、Abe Ikuro、Morita Hiroyuki
    • Journal Title

      Chemistry & Biodiversity

      Volume: 16 Issue: 4

    • DOI

      10.1002/cbdv.201800657

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new sterol from the Vietnamese marine sponge Xestospongia testudinaria and its biological activities2019

    • Author(s)
      Nguyen, H.M., Ito, T., Win, N.N., Vo, H.Q., Nguyen, H.T., Morita, H.
    • Journal Title

      Nat. Prod. Res.

      Volume: 33 Issue: 8 Pages: 1175-1181

    • DOI

      10.1080/14786419.2018.1465057

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and olfactory properties of Phantolide analogues in racemic and optically active forms2019

    • Author(s)
      Kawasaki Masashi、Kuroyanagi Saki、Ito Takuya、Morita Hiroyuki、Tanaka Yasuo、Toyooka Naoki
    • Journal Title

      Flavour and Fragrance Journal

      Volume: 34 Issue: 2 Pages: 113-123

    • DOI

      10.1002/ffj.3483

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three new abietane-type diterpenoids from the leaves of Indonesian Plectranthus scutellarioides2018

    • Author(s)
      Ito Takuya、Rakainsa Senda Kartika、Nisa Khoirun、Morita Hiroyuki
    • Journal Title

      Fitoterapia

      Volume: - Pages: 146-150

    • DOI

      10.1016/j.fitote.2018.02.013

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Two new pyrrolo-2-aminoimidazoles, Clathriroles A and B, from marine sponge, Clathria prolifera collected in Myanmar2018

    • Author(s)
      Woo, S.-Y., Win, N. N., Wong, C. P., Ito, T., Hoshino, S., Ngwe, H., Aye, A. A., Han, N., Zhang, H., Hayashi, F., Abe, I., Morita, H.
    • Journal Title

      J. Nat. Med.,

      Volume: 72 Issue: 3 Pages: 803-807

    • DOI

      10.1007/s11418-018-1205-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar2018

    • Author(s)
      Win Nwet Nwet、Woo So-Yeun、Ngwe Hla、Prema、Wong Chin Piow、Ito Takuya、Okamoto Yasuko、Tanaka Masami、Imagawa Hiroshi、Asakawa Yoshinori、Abe Ikuro、Morita Hiroyuki
    • Journal Title

      Fitoterapia

      Volume: 123 Pages: 308-313

    • DOI

      10.1016/j.fitote.2018.03.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum2018

    • Author(s)
      Lu Wanli、Alanzi Abdullah R.、Abugrain Mostafa E.、Ito Takuya、Mahmud Taifo
    • Journal Title

      Applied Microbiology and Biotechnology

      Volume: 102 Issue: 24 Pages: 10589-10601

    • DOI

      10.1007/s00253-018-9375-9

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New phloroglucinol derivatives from Indonesian Baeckea frutescens2017

    • Author(s)
      T. Ito, K. Nisa, S. K. Rakainsa, Subehan, H. Morita.
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 8 Pages: 1177-1181

    • DOI

      10.1016/j.tet.2017.01.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera (Pit.)2017

    • Author(s)
      H.T. Nguyen, D.V. Ho, H. Q. Vo, A. T. Le, H. M. Nguyen, T. Kodama, T. Ito, H. Morita, A. Rall.
    • Journal Title

      Pharmaceutical Biology

      Volume: 55 Issue: 1 Pages: 787-791

    • DOI

      10.1080/13880209.2017.1279673

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-influenza virus activity of extracts from stems of Jatropha multifida Linn. collected in Myanmar2017

    • Author(s)
      M. Shoji, S. Woo, A. Masuda, N. N. Win, H. Ngwe, E. Takahashi, H. Kido, H. Morita, T. Ito.
    • Journal Title

      BMC Complem Altern Med

      Volume: 17 Issue: 1 Pages: 96-96

    • DOI

      10.1186/s12906-017-1612-8

    • NAID

      120006814109

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides2017

    • Author(s)
      Zhang Lihan、Hashimoto Takuya、Qin Bin、Hashimoto Junko、Kozone Ikuko、Kawahara Teppei、Okada Masahiro、Awakawa Takayoshi、Ito Takuya、Asakawa Yoshinori、Ueki Masashi、Takahashi Shunji、Osada Hiroyuki、Wakimoto Toshiyuki、Ikeda Haruo、Shin-ya Kazuo、Abe Ikuro
    • Journal Title

      Angewandte Chemie

      Volume: 129 Issue: 7 Pages: 1766-1771

    • DOI

      10.1002/ange.201611371

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis and odor properties of Phantolide analogues2017

    • Author(s)
      Kawasaki Masashi、Kuroyanagi Saki、Ito Takuya、Morita Hiroyuki、Tanaka Yasuo、Toyooka Naoki
    • Journal Title

      Tetrahedron

      Volume: 73 Issue: 15 Pages: 2089-2099

    • DOI

      10.1016/j.tet.2017.02.055

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new benzophenanthridine alkaloid from Caloncoba glauca.2017

    • Author(s)
      Agbo, J. B. P. A. A., Mpetga, J. D. S., Bikanga, R., Tchuenguem, R. T., Tsafack R. B. N, Awoufack, M. D., Dzoyem, J. P., Ito, T., Morita, H., Tane, P.
    • Journal Title

      Nat. Prod. Comm.

      Volume: 12 Pages: 367-368

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities2017

    • Author(s)
      Kodama Takeshi、Ito Takuya、Dibwe Dya Fita、Woo So-Yeun、Morita Hiroyuki
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 11 Pages: 2397-2400

    • DOI

      10.1016/j.bmcl.2017.04.017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum2017

    • Author(s)
      Ho Viet Duc、Hoang Thi Nhu Hanh、Vo Quoc Hung、Phan Van Kiem、Le Tuan Anh、Pham Viet Ty、Nguyen Minh Hien、Kodama Takeshi、Ito Takuya、Morita Hiroyuki、Raal Ain、Nguyen Thi Hoai
    • Journal Title

      Phytochemistry

      Volume: 144 Pages: 113-118

    • DOI

      10.1016/j.phytochem.2017.09.004

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities2017

    • Author(s)
      Win Nwet Nwet、Ito Takuya、Ngwe Hla、Win Yi Yi、Prema、Okamoto Yasuko、Tanaka Masami、Asakawa Yoshinori、Abe Ikuro、Morita Hiroyuki
    • Journal Title

      Fitoterapia

      Volume: 122 Pages: 34-39

    • DOI

      10.1016/j.fitote.2017.08.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Collaboration with some universities of Myanmar in natural product research.2017

    • Author(s)
      Ito, Takuya
    • Organizer
      Symposium on traditional medicine and primary healthcare in Toyama and Myanmar (JICA partnership program)(富山)
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Phytochemical study on Baeckea frutescens collected in Indonesia.2017

    • Author(s)
      Ito T, Khoirun N, Morita H.
    • Organizer
      The 58th Annual Meeting of the American Society of Pharmacognosy(ポートランド、USA)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Book] 生薬・薬用植物研究の最新動向2017

    • Author(s)
      高松智(編集)、伊藤卓也 共著
    • Total Pages
      229
    • Publisher
      シーエムシー出版
    • ISBN
      9784781312644
    • Related Report
      2017 Research-status Report
  • [Remarks] 大阪大谷大学薬学部

    • URL

      http://www.osaka-ohtani.ac.jp/department/teacher/pharmacy/ph_itoutaku.html

    • Related Report
      2017 Research-status Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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