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Identification of target molecules and functions of Tomosaponin AIII

Research Project

Project/Area Number 17K08339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Natural medicines
Research InstitutionOita University

Principal Investigator

Ishizaki Toshimasa  大分大学, 医学部, 教授 (70293876)

Co-Investigator(Kenkyū-buntansha) 花田 克浩  大分大学, 医学部, 助教 (90581009)
寺林 健  大分大学, 医学部, 助教 (40452429)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsチモサポニン / 細胞運動 / 細胞接着 / 細胞内情報伝達 / カルシウム / 天然化合物 / Rac / ERK / ステロイド配糖体 / カルシウムシグナリング / AKT / インテグリン / 生薬 / アクチン細胞骨格 / 血管新生
Outline of Final Research Achievements

There are many cases where traditional drugs such as Japanese and Chinese medicines are effective against diseases that are difficult to treat with drugs used in Western medicine. On the other hand, traditional drugs have many components, which makes it difficult to provide a comprehensive understanding of their pharmacological actions and their effectiveness as therapeutic agents. During the period of this study, we found that Timosaponin A3 and baicalein suppress cell migration through upstresm or downstream inhibition of small GTPase Rac, respectively.

Academic Significance and Societal Importance of the Research Achievements

漢方の基本原理とされている理論は、経験的に後付けされたものが多い。しかし、その作用は多彩で、有効であることも広く理解されている。本研究では、漢方薬に含まれる天然化合物の漢方薬を効果的に処方するには、含まれる天然化合物の作用を明らかにすることが不可欠であり、本研究は、漢方薬の作用の科学的に理解を深めることに貢献したものと考えている。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.2020

    • Author(s)
      Thumkeo, D., Katsura, Y., Nishimura, Y., Kanchanawong, P., Tohyama, K., Ishizaki, T., Kitajima, S., Takahashi, C., Hirata, T., Watanabe, N., Krummel, M. F., and Narumiya, S.
    • Journal Title

      Sci. Adv.

      Volume: 6 Issue: 1 Pages: 2432-2432

    • DOI

      10.1126/sciadv.aay2432

    • NAID

      120006777011

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of Chromosomal DNA Fragmentation in Apoptosis by Pulsed-Field Gel Electrophoresis.2020

    • Author(s)
      Terabayashi T, Tokumaru A, Ishizaki T, Hanada
    • Journal Title

      Methods Mol Biol.

      Volume: 2119 Pages: 89-99

    • DOI

      10.1007/978-1-0716-0323-9_8

    • ISBN
      9781071603222, 9781071603239
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion2019

    • Author(s)
      Kimura Toshihide、Yamaoka Mami、Terabayashi Takeshi、Kaibuchi Kozo、Ishikawa Tomohisa、Ishizaki Toshimasa
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 9 Pages: 1532-1537

    • DOI

      10.1248/bpb.b19-00242

    • NAID

      130007700076

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-09-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IRR is involved in glucose-induced endocytosis after insulin secretion2019

    • Author(s)
      Yamaoka Mami、Terabayashi Takeshi、Nishioka Tomoki、Kaibuchi Kozo、Ishikawa Tomohisa、Ishizaki Toshimasa、Kimura Toshihide
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 140 Issue: 3 Pages: 300-304

    • DOI

      10.1016/j.jphs.2019.07.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumour microenvironment.2018

    • Author(s)
      Terabayashi T., Hanada K., Motani K., Kosako H., Yamaoka M., Kimura T. and Ishizaki T.
    • Journal Title

      Genes to Cells

      Volume: 印刷中 Issue: 6 Pages: 466-479

    • DOI

      10.1111/gtc.12584

    • NAID

      130007811814

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] バイカレインは乳がん細胞の形態可塑性と細胞運動を抑制する2020

    • Author(s)
      寺林 健
    • Organizer
      第93回日本薬理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Role of rho-mdia1 signaling to maintain cardiac function in response to pressure overload in mice2019

    • Author(s)
      I Abe, T Terabayashi, Y Teshima, Y Ishii, M Miyoshi, S Kira, H Kondo, S Saito, K Yufu, N Takahashi, T Ishizaki
    • Organizer
      ESC Congress 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膵B細胞におけるグルコース誘導性エンドサイトーシスの解析2017

    • Author(s)
      山岡真美、寺林健、石崎敏理、木村俊秀
    • Organizer
      第40回 日本分子生物学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膵B細胞におけるグルコース誘導性エンドサイトーシスの分子メカニズムの解析2017

    • Author(s)
      山岡真美、荒巻千香子、姫野冴美、寺林健、石崎敏理、木村俊秀
    • Organizer
      第60回 日本糖尿病学会年次学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膵B細胞におけるGDP型Rab27a新規結合タンパク質の機能解析2017

    • Author(s)
      姫野冴美、山岡真美、寺林健、石崎敏理、木村俊秀
    • Organizer
      第90回 日本薬理学会年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膵B細胞におけるエンドサイトーシスの解析.2017

    • Author(s)
      荒巻千香子、山岡真美、姫野冴美、寺林健、石崎敏理、木村俊秀
    • Organizer
      第90回 日本薬理学会年会
    • Related Report
      2017 Research-status Report
  • [Patent(Industrial Property Rights)] 化合物およびそれを利用した医薬2020

    • Inventor(s)
      小路弘行、石崎敏理、他6名
    • Industrial Property Rights Holder
      株式会社大分大学先端医学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 狂犬病治療のための環状アミド化合物およびその方法2019

    • Inventor(s)
      小路弘行、石崎敏理、他6名
    • Industrial Property Rights Holder
      株式会社大分大学先端医学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-103958
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] RSウイルス感染症の治療のための化合物およびその方法2019

    • Inventor(s)
      小路弘行、石崎敏理、他6名
    • Industrial Property Rights Holder
      株式会社大分大学先端医学研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-103959
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 狂犬病の治療のための化合物およびその方法2018

    • Inventor(s)
      小路弘行、石崎敏理、他6名
    • Industrial Property Rights Holder
      株式会社大分大学先端医学研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2018
    • Acquisition Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2017-04-28   Modified: 2021-02-19  

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