| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this project, we successfully discovered six new antimalarial compounds form 3 different fungal cultured broths. From the cultured broth of FKI-7019 strain, we isolated two new linear lipopeptides named kozupeptins A and B, having potent in vitro and in vivo antimalarial activity. From the cultured broth of strain A, we found two new cyclic tetrapeptides showing moderate in vitro antimalarial activity. From the cultured broth of strain B, we found two new heterocyclic compounds displaying moderate in vitro antimalarial activity. We also picked up three known compounds as antileishmanial agents active against Leishmania major in vitro.
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