Search for seeds of drugs for tropical diseases from Kitasato microbial library
| Project/Area Number |
17K08343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Natural medicines
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マラリア / リーシュマニア / 微生物代謝産物 / 天然物化学 / 微生物創薬 / 新規化合物 / 糸状菌代謝産物 / 新規ペプチド化合物 / 抗生物質 / リーシュマニア症 |
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| Outline of Final Research Achievements |
In this project, we successfully discovered six new antimalarial compounds form 3 different fungal cultured broths. From the cultured broth of FKI-7019 strain, we isolated two new linear lipopeptides named kozupeptins A and B, having potent in vitro and in vivo antimalarial activity. From the cultured broth of strain A, we found two new cyclic tetrapeptides showing moderate in vitro antimalarial activity. From the cultured broth of strain B, we found two new heterocyclic compounds displaying moderate in vitro antimalarial activity. We also picked up three known compounds as antileishmanial agents active against Leishmania major in vitro.
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| Academic Significance and Societal Importance of the Research Achievements |
得られた創薬シード化合物は熱帯病治療薬の開発に特化した非営利団体の支援および製薬企業との共同研究によって国際的な開発研究へと展開していくことで各原虫症治療薬の開発に繋がることが期待される。開発された治療薬はマラリアおよびリーシュマニア症による人的被害を軽減することで開発途上国の保健衛生の向上に繋がり、人類の福祉として国際貢献をするものである。
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Report
(4 results)
Research Products
(9 results)
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[Presentation] New Antimalarial Lipopeptides Produced by Paracamarospurium Species: Isolation, Structural Elucidation, Efficient Total Synthesis, and Biological Activity2018
Author(s)
Yumi Hayashi, Tomoyasu Hirose, Wataru Fukasawa, Masato Iwatsuki, Kenichi Nonaka, Rei Hokari, Aki Ishiyama, Kazuro Shiomi, Satoshi Omura, Toshiaki Sunazuka
Organizer
The 14th International Kyoto Conference on New Aspects of Organic Chemistry (IKCOC-14)
Related Report
Int'l Joint Research
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