| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The search for new antifungal and antiprotozoal natural products from marine organisms was performed. As a result, twenty-six new natural products were isolated from marine dinoflagellates and sponges, and the structures of six new compounds were elucidated. Among them, one macrolide from dinoflagellates and two alkaloids from a sponge exhibited cytotoxicity against murine leukemia cell line L1210 in vitro. While one alkaloid from a sponge exhibited antimalarial activities against a drug-resistant and a drug-sensitive strains of Plasmodium falciparum. The investigation about antifungal and antiprotozoal activities of other new compounds were currently in progress.
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