Development of an advanced protein linking technology for generating innovative biopharmaceuticals
| Project/Area Number |
17K08368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 抗体 / バイオ医薬 / タンパク質工学 / 遺伝子 / 蛋白質 / バイオテクノロジー |
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| Outline of Final Research Achievements |
In this study, we aimed to establish the technology for the development of next-generation antibody therapeutics by advancing our protein linking method based on the hetero-tetramerization of the peptides. First, we succeeded in preparing the trispecific antibody by imparting different specificity to the previously produced bispecific antibody. Furthermore, we successfully produced the functional bispecific antibody-drug conjugate, indicating that our protein linking method is useful for construction of drug delivery system.
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| Academic Significance and Societal Importance of the Research Achievements |
抗体医薬は、がんやリウマチなど治療が難しい疾患に対する副作用の少ない治療薬として期待され、その重要性はますます高まっている。その一方で、高額な治療費が課題とされていることから、治療費の低減に向けた取り組みは医療経済的観点から重要である。本研究では、抗体高機能化技術の高度化を達成できたことから、抗体医薬の機能向上による低用量化を通じて、抗体治療の低コスト化に貢献できると期待される。
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Build-up Functionalization of anti-EGFR × anti-CD3 Bispecific Diabodies by Integrating High-Affinity Mutants and Functional Molecular Formats.2020
Author(s)
Asano R, Hosokawa K, Taki S, Konno S, Shimomura I, Ogata H, Okada M, Arai K, Nakanishi T, Onitsuka M, Omasa T, Umetsu M, Kumagai I.
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Journal Title
Sci. Rep.
Volume: 10(1)
Issue: 1
Pages: 4913-4913
DOI
Related Report
Peer Reviewed / Open Access
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