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Peptide foldamers in drug discovery

Research Project

Project/Area Number 17K08385
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Drug development chemistry
Research InstitutionNational Institute of Health Sciences

Principal Investigator

Demizu Yosuke  国立医薬品食品衛生研究所, 有機化学部, 部長 (90389180)

Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsペプチド / 非天然型アミノ酸 / 二次構造 / DDS / 抗菌ペプチド / PROTAC / ステープルペプチド / タンパク質分解誘導剤 / 構造制御 / 中分子ペプチド / ヘリカル構造 / PPI阻害 / 分解誘導剤 / 核内受容体 / DDSキャリア / Post-modification / 二次構造解析
Outline of Final Research Achievements

Next-generation medium-sized molecular peptide drugs are being developed around the world. To facilitate their practical application, well-controlled manufacturing methods and quality and safety evaluation methods based on the characteristics of these drugs should be established. In particular, peptide design which is able to form stable helical structures is one of the most important approaches to develop highly functionalized peptide-based drugs. In this research, helix-stabilized peptides were developed for application using DDS carriers, antimicrobials, and peptide-based PROTACs.

Academic Significance and Societal Importance of the Research Achievements

本研究により得られた成果は、リードペプチド探索の方法、スクリーリングヒット率の向上に貢献でき、中分子ペプチド医薬品の開発効率化に資するためのレギュラトリーサイエンス研究の推進(品質、有効性、安全性の確保)にも繋げることができる。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (264 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (65 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 65 results,  Open Access: 24 results,  Acknowledgement Compliant: 2 results) Presentation (193 results) (of which Int'l Joint Research: 20 results,  Invited: 12 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] <i>N</i>-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride2021

    • Author(s)
      Yokoo Hidetomo、Yamamoto Eiichi、Masada Sayaka、Uchiyama Nahoko、Tsuji Genichiro、Hakamatsuka Takashi、Demizu Yosuke、Izutsu Ken-ichi、Goda Yukihiro
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 69 Issue: 9 Pages: 872-876

    • DOI

      10.1248/cpb.c21-00289

    • NAID

      130008081978

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2021-09-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 2): Establishment of a Quantitative Method for Lorazepam Using HPLC Analysis2021

    • Author(s)
      Maniwa Aika、Tsuji Genichiro、Ito Takahito、Uchiyama Nahoko、Hosoe Junko、Ohtsuki Takashi、Matsufuji Hiroshi、Demizu Yosuke、Goda Yukihiro
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 141 Issue: 7 Pages: 961-970

    • DOI

      10.1248/yakushi.21-00010

    • NAID

      130008059963

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2021-07-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Miroestrol Quantification in <i>Pueraria mirifica</i> Crude Drugs and Products by Single-Reference UPLC/PDA/MS Using Relative Molar Sensitivities to Kwakhurin2021

    • Author(s)
      Masada Sayaka、Hosoe Junko、Arai Ryoko、Demizu Yosuke、Hakamatsuka Takashi、Goda Yukihiro、Uchiyama Nahoko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 69 Issue: 6 Pages: 573-580

    • DOI

      10.1248/cpb.c21-00160

    • NAID

      130008046432

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2021-06-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 1): Establishment of a Quantitative Test Method for Clonidine Hydrochloride Using HPLC Analysis2021

    • Author(s)
      Maniwa Aika、Tsuji Genichiro、Ito Takahito、Uchiyama Nahoko、Hosoe Junko、Ohtsuki Takashi、Matsufuji Hiroshi、Demizu Yosuke、Goda Yukihiro
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 141 Issue: 4 Pages: 591-598

    • DOI

      10.1248/yakushi.20-00237

    • NAID

      130008013879

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2021-04-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Approach to Establishment of Control Strategy for Oral Solid Dosage Forms Using Continuous Manufacturing2021

    • Author(s)
      Ishimoto Hayato、Kano Manabu、Sugiyama Hirokazu、Takeuchi Hirofumi、Terada Katsuhide、Aoyama Atsushi、Shoda Takuji、Demizu Yosuke、Shimamura Jinen、Yokoyama Reiji、Miyamoto Yuji、Hasegawa Koji、Serizawa Masaru、Unosawa Kazuomi、Osaki Kazuo、Asai Naochika、Matsuda Yoshihiro
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 69 Issue: 2 Pages: 211-217

    • DOI

      10.1248/cpb.c20-00824

    • NAID

      130007979432

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2021-02-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor2021

    • Author(s)
      Kurohara Takashi、Ito Takahito、Tsuji Genichiro、Misawa Takashi、Yokoo Hidetomo、Yanase Yuta、Shoda Takuji、Sakai Takatoshi、Hosoe Junko、Uchiyama Nahoko、Akiyama Hiroshi、Demizu Yosuke
    • Journal Title

      Bioorganic &amp; Medicinal Chemistry

      Volume: 49 Pages: 116425-116425

    • DOI

      10.1016/j.bmc.2021.116425

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 64 Issue: 21 Pages: 15868-15882

    • DOI

      10.1021/acs.jmedchem.1c01206

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021

    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 8772-8772

    • DOI

      10.3390/ijms22168772

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus2021

    • Author(s)
      Ikeda Kentaro、Shoda Takuji、Demizu Yosuke、Tsuji Genichiro
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 48 Pages: 128259-128259

    • DOI

      10.1016/j.bmcl.2021.128259

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents2021

    • Author(s)
      Kuriyama Masami、Onomura Osamu、Matsuo Kasumi、Yamamoto Kosuke、Demizu Yosuke、Nishida Koyo
    • Journal Title

      Synthesis

      Volume: 53 Issue: 23 Pages: 4449-4460

    • DOI

      10.1055/a-1548-8362

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure?activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine2021

    • Author(s)
      Yokoo Hidetomo、Hirano Motoharu、Ohoka Nobumichi、Misawa Takashi、Demizu Yosuke
    • Journal Title

      Journal of Peptide Science

      Volume: 27 Issue: 12 Pages: 1-6

    • DOI

      10.1002/psc.3360

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Agonist-Based PROTACs Targeting Liver X Receptor2021

    • Author(s)
      Xu Hanqiao、Ohoka Nobumichi、Yokoo Hidetomo、Nemoto Kanako、Ohtsuki Takashi、Matsufuji Hiroshi、Naito Mikihiko、Inoue Takao、Tsuji Genichiro、Demizu Yosuke
    • Journal Title

      Frontiers in Chemistry

      Volume: 9 Pages: 674967-674967

    • DOI

      10.3389/fchem.2021.674967

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of ciclesonide analogues that block SARS-CoV-2 RNA replication2021

    • Author(s)
      Tsuji Genichiro、Yonemitsu Kenzo、Ito Takahito、Yanase Yuta、Uema Masashi、Ohoka Nobumichi、Inoue Takao、Asakura Hiroshi、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 43 Pages: 128052-128052

    • DOI

      10.1016/j.bmcl.2021.128052

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021

    • Author(s)
      Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
    • Journal Title

      Molecules

      Volume: 26 Issue: 2 Pages: 444-444

    • DOI

      10.3390/molecules26020444

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue2021

    • Author(s)
      Moriya Shun-suke、Shibasaki Hatsune、Kohara Misaki、Kuwata Keiko、Imamura Yasutada、Demizu Yosuke、Kurihara Masaaki、Kittaka Atsushi、Sugiyama Toru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 39 Pages: 127850-127850

    • DOI

      10.1016/j.bmcl.2021.127850

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of novel estrogen receptor antagonists with acetal containing biphenylmethane skeleton2021

    • Author(s)
      Yuyama Materu、Misawa Takashi、Demizu Yosuke、Kanaya Takayuki、Kurihara Masaaki
    • Journal Title

      Results in Chemistry

      Volume: 3 Pages: 100124-100124

    • DOI

      10.1016/j.rechem.2021.100124

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids2021

    • Author(s)
      Yokoo Hidetomo、Hirano Motoharu、Misawa Takashi、Demizu Yosuke
    • Journal Title

      ChemMedChem

      Volume: 16 Issue: 8 Pages: 1226-1233

    • DOI

      10.1002/cmdc.202000940

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021

    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Molecular Cell

      Volume: 81 Issue: 7 Pages: 1411-1424.e7

    • DOI

      10.1016/j.molcel.2021.01.023

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021

    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 12 Issue: 2 Pages: 236-241

    • DOI

      10.1021/acsmedchemlett.0c00605

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transition Metal-Free O-Arylation of Quinoxalin-2-ones with Diaryliodonium Salts2021

    • Author(s)
      Kuriyama Msami、Mochizuki Yuki、Miyagi, Tsubasa、Yamamoto Kosuke、Demizu Yosuke、Onomura Osamu
    • Journal Title

      Heterocycles

      Volume: 103 Issue: 1 Pages: 502-502

    • DOI

      10.3987/com-20-s(k)26

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021

    • Author(s)
      Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Methods Mol. Biol.

      Volume: 2365 Pages: 331-347

    • DOI

      10.1007/978-1-0716-1665-9_18

    • ISBN
      9781071616642, 9781071616659
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amine skeleton-based c-di-GMP derivatives as biofilm formation inhibitors2021

    • Author(s)
      Ikeda Kentaro、Yanase Yuta、Hayashi Katsuhiko、Hara-Kudo Yukiko、Tsuji Genichiro、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 32 Pages: 127713-127713

    • DOI

      10.1016/j.bmcl.2020.127713

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temperature-Dependent Formation of <i>N</i>-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets2020

    • Author(s)
      Abe Yasuhiro、Yamamoto Eiichi、Yoshida Hiroyuki、Usui Akiko、Tomita Naomi、Kanno Hitomi、Masada Sayaka、Yokoo Hidetomo、Tsuji Genichiro、Uchiyama Nahoko、Hakamatsuka Takashi、Demizu Yosuke、Izutsu Ken-ichi、Goda Yukihiro、Okuda Haruhiro
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 68 Issue: 10 Pages: 1008-1012

    • DOI

      10.1248/cpb.c20-00431

    • NAID

      130007920176

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2020-10-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Facile Synthesis of Kwakhurin, a Marker Compound of <i>Pueraria mirifica</i> and Its Quantitative NMR Analysis for Standardization as a Reagent2020

    • Author(s)
      Tsuji Genichiro、Yusa Masaaki、Masada Sayaka、Yokoo Hidetomo、Hosoe Junko、Hakamatsuka Takashi、Demizu Yosuke、Uchiyama Nahoko
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 68 Issue: 8 Pages: 797-801

    • DOI

      10.1248/cpb.c20-00346

    • NAID

      130007883280

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2020-08-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Photoswitchable Estrogen Receptor Ligands2020

    • Author(s)
      K. Tsuchiya, T. Umeno, G. Tsuji, H. Yokoo, M. Tanaka, K. Fukuhara, Y. Demizu, T. Misawa
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 68 Issue: 4 Pages: 398-402

    • DOI

      10.1248/cpb.c19-01108

    • NAID

      130007824936

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2020-04-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton2020

    • Author(s)
      Terui Ryusei、Yanase Yuta、Yokoo Hidetomo、Suhara Yoshitomo、Makishima Makoto、Demizu Yosuke、Misawa Takashi
    • Journal Title

      ChemMedChem

      Volume: 16 Issue: 3 Pages: 458-462

    • DOI

      10.1002/cmdc.202000567

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rational Design of Helix‐Stabilized Antimicrobial Peptide Foldamers Containing α,α‐Disubstituted Amino Acids or Side‐Chain Stapling2020

    • Author(s)
      Hirano Motoharu、Saito Chihiro、Goto Chihiro、Yokoo Hidetomo、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
    • Journal Title

      ChemPlusChem

      Volume: 85 Issue: 12 Pages: 2731-2736

    • DOI

      10.1002/cplu.202000749

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Chiral α‐Trifluoromethyl α,α‐Disubstituted α‐Amino Acids and Conformational Analysis of L‐Leu‐Based Peptides with ( R )‐ or ( S )‐α‐Trifluoromethylalanine2020

    • Author(s)
      Ueda Atsushi、Ikeda Misuzu、Kasae Takuya、Doi Mitsunobu、Demizu Yosuke、Oba Makoto、Tanaka Masakazu
    • Journal Title

      ChemistrySelect

      Volume: 5 Issue: 35 Pages: 10882-10886

    • DOI

      10.1002/slct.202002888

    • NAID

      120006988512

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin2020

    • Author(s)
      Mizuno Mirei、Mori Kazunori、Tsuchiya Keisuke、Takaki Takashi、Misawa Takashi、Demizu Yosuke、Shibanuma Motoko、Fukuhara Kiyoshi
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 36 Pages: 23164-23174

    • DOI

      10.1021/acsomega.0c02936

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] De Novo Design of Cell‐Penetrating Foldamers2020

    • Author(s)
      Yokoo Hidetomo、Misawa Takashi、Demizu Yosuke
    • Journal Title

      The Chemical Record

      Volume: 20 Issue: 9 Pages: 912-921

    • DOI

      10.1002/tcr.202000047

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors2020

    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Issue: 15 Pages: 115595-115595

    • DOI

      10.1016/j.bmc.2020.115595

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020

    • Author(s)
      Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Pharmaceuticals

      Volume: 13 Issue: 4 Pages: 74-74

    • DOI

      10.3390/ph13040074

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Copper‐Catalyzed Enantioselective Synthesis of Oxazolines from Aminotriols via Asymmetric Desymmetrization2020

    • Author(s)
      Yamamoto Kosuke、Tsuda Yutaro、Kuriyama Masami、Demizu Yosuke、Onomura Osamu
    • Journal Title

      Chemistry An Asian Journal

      Volume: 15 Issue: 6 Pages: 840-846

    • DOI

      10.1002/asia.201901742

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and Synthesis of 4-(2-Pyrrolyl)-4-phenylheptane Derivatives as Estrogen Receptor Antagonists2020

    • Author(s)
      Tsuji Genichiro、Demizu Yosuke、Naganuma Miyako、Yokoo Hidetomo、Misawa Takashi、Matsuno Kenji
    • Journal Title

      HETEROCYCLES

      Volume: 101 Issue: 2 Pages: 429-429

    • DOI

      10.3987/com-19-14121

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020

    • Author(s)
      Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      Journal of Cell Biology

      Volume: 219 Issue: 9 Pages: 1-23

    • DOI

      10.1083/jcb.201912144

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020

    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
    • Journal Title

      Oncogene

      Volume: - Issue: 19 Pages: 3867-3878

    • DOI

      10.1038/s41388-020-1253-0

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Refining Calibration Procedures of Circular Dichroism Spectrometer to Improve Usability2019

    • Author(s)
      K. Sakai-Kato,* K. Yoshida, T. Ohgita, Y. Takechi-Haraya, Y. Demizu, H. Saito
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 11 Pages: 1275-1278

    • DOI

      10.2116/analsci.19N022

    • NAID

      130007743081

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-11-10
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of an Impurity, <i>N</i>-Nitrosodimethylamine, in Valsartan Drug Substances and Associated Products Using GC-MS2019

    • Author(s)
      T. Tsutsumi, H. Akiyama,* Y. Demizu, N. Uchiyama, S. Masada, G. Tsuji, R. Arai, Y. Abe, Y. Haraya, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 42 Issue: 4 Pages: 547-551

    • DOI

      10.1248/bpb.b19-00006

    • NAID

      130007622070

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2019-04-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019

    • Author(s)
      N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
    • Journal Title

      ACS Chem. Biol.

      Volume: 14 Issue: 12 Pages: 2822-2832

    • DOI

      10.1021/acschembio.9b00704

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of amphipathic antimicrobial peptide foldamers based on Magainin 2 sequence2019

    • Author(s)
      C. Goto, M. Hirano, K. Hayashi, Y. Kikuchi, Y. Hara-Kudo, T. Misawa,* Y. Demizu*
    • Journal Title

      ChemMedChem

      Volume: 14 Issue: 22 Pages: 1911-1916

    • DOI

      10.1002/cmdc.201900460

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of beta-amyloid-induced neurotoxicity by planar analogues of procyanidin B32019

    • Author(s)
      M. Mizuno, K. Mori, T. Misawa, Y. Demizu, M. Shibanuma, K. Fukuhara*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 29 Issue: 18 Pages: 2659-2663

    • DOI

      10.1016/j.bmcl.2019.07.038

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its medicines2019

    • Author(s)
      S. Masada, G. Tsuji, R. Arai, N. Uchiyama,* Y. Demizu,* T. Tsutsumi, Y. Abe, H. Akiyama, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 11852-11852

    • DOI

      10.1038/s41598-019-48344-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Palladium-catalyzed synthesis of deuterated alkenes through deuterodechlorination of alkenyl chlorides2019

    • Author(s)
      M. Kuriyama,* G. Yano, H. Kiba, T. Morimoto, K. Yamamoto, Y. Demizu, O. Onomura*
    • Journal Title

      Org. Process Res. Dev.

      Volume: 23 Issue: 8 Pages: 1552-1557

    • DOI

      10.1021/acs.oprd.9b00193

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019

    • Author(s)
      T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
    • Journal Title

      Chem. Commun.

      Volume: 55 Issue: 54 Pages: 7792-7795

    • DOI

      10.1039/c9cc02203a

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues2019

    • Author(s)
      Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
    • Journal Title

      Med Chem Comm

      Volume: 印刷中 Issue: 6 Pages: 896-900

    • DOI

      10.1039/c9md00166b

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facile Synthesis of α-exo-Methylene Ketones from α,α-Disubstituted Allyl Alcohols  by Electrochemical Oxidative Migration2019

    • Author(s)
      Yamamoto, K.; Kikuchi, N.; Hamamizu, T.; Yoshimatsu, H.; Kuriyama, M.; Demizu, Y.; Onomura, O.
    • Journal Title

      ChemElectroChem

      Volume: 印刷中 Issue: 16 Pages: 4169-4172

    • DOI

      10.1002/celc.201900172

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives2018

    • Author(s)
      H. Kobayashi, T. Misawa,* M. Oba, N. Hirata, Y. Kanda, M. Tanaka, K. Matsuno, Y. Demizu*
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 5 Pages: 575-580

    • DOI

      10.1248/cpb.c18-00079

    • NAID

      130006729546

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2018-05-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018

    • Author(s)
      K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
    • Journal Title

      J Med Chem.

      Volume: 61 Issue: 2 Pages: 576-582

    • DOI

      10.1021/acs.jmedchem.7b00413

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton2018

    • Author(s)
      Eto Ryo、Misawa Takashi、Noguchi-Yachide Tomomi、Ohoka Nobumichi、Kurihara Masaaki、Naito Mikihiko、Tanaka Masakazu、Demizu Yosuke
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 26 Issue: 8 Pages: 1638-1642

    • DOI

      10.1016/j.bmc.2018.02.010

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The extent of helical induction caused by introducing a-aminoisobutyric acid into an oligovaline sequence2018

    • Author(s)
      G. Tsuji, T. Misawa, M. Doi, Y. Demizu*
    • Journal Title

      ACS Omega

      Volume: 3 Issue: 6 Pages: 6395-6399

    • DOI

      10.1021/acsomega.8b01030

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.2018

    • Author(s)
      Tsuji G, Hattori T, Kato M, Hakamata W, Inoue H, Naito M, Kurihara M, Demizu Y, Shoda T.
    • Journal Title

      Bioorg Med Chem.

      Volume: 26 Issue: 20 Pages: 5494-5498

    • DOI

      10.1016/j.bmc.2018.09.028

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon.2018

    • Author(s)
      Misawa T, Tsuji G, Takahashi T, Ochiai E, Takagi KI, Horie K, Kakuda S, Takimoto-Kamimura M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg Med Chem.

      Volume: 26 Issue: 23-24 Pages: 6146-6152

    • DOI

      10.1016/j.bmc.2018.11.008

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N-H...ethereal O type hydrogen bond2018

    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, T. Kato, Y. Demizu, M. Tanaka*
    • Journal Title

      Org. Lett.

      Volume: 20 Issue: 24 Pages: 7830-7834

    • DOI

      10.1021/acs.orglett.8b03331

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rational design and synthesis of post-functionalizable peptide foldamers as helical templates2017

    • Author(s)
      T. Misawa,* Y. Kanda, Y. Demizu*
    • Journal Title

      Bioconj. Chem.

      Volume: 28 Issue: 12 Pages: 3029-3035

    • DOI

      10.1021/acs.bioconjchem.7b00621

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Right-handed and left-handed helical structures with fourteen (R)-chiral centers2017

    • Author(s)
      R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 72 Pages: 18120-18124

    • DOI

      10.1002/chem.201705306

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preorganized cyclic alpha,alpha-disubstituted alpha-amino acids bearing functionalized side chains that act as peptide-helix inducers2017

    • Author(s)
      H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*
    • Journal Title

      J. Org. Chem.

      Volume: 82 Issue: 19 Pages: 10722-10726

    • DOI

      10.1021/acs.joc.7b01946

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017

    • Author(s)
      Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 22 Pages: 4985-4988

    • DOI

      10.1016/j.bmcl.2017.10.011

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017

    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 18 Pages: 4478-4481

    • DOI

      10.1016/j.bmcl.2017.08.001

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic alpha,alpha-disubstituted alpha-amino acid residues2017

    • Author(s)
      T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 17 Pages: 3950-3953

    • DOI

      10.1016/j.bmcl.2017.07.074

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA2017

    • Author(s)
      Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Issue: 15 Pages: 3337

    • DOI

      10.1016/j.bmcl.2017.06.015

    • URL

      https://pure.teikyo.jp/en/publications/638613df-5284-4b15-9344-cc9d91be9b1f

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low pH-responsive change in side chain structure of an amino acid from cyclic acetal to acyclic diol leads to conformational change in a peptide from a helical to random structure2017

    • Author(s)
      K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*
    • Journal Title

      Org. Biomol. Chem.

      Volume: 15 Issue: 30 Pages: 6302-6305

    • DOI

      10.1039/c7ob01374d

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety2017

    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 26 Pages: 8108-8114

    • DOI

      10.1002/slct.201700832

    • NAID

      120006988059

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells2017

    • Author(s)
      Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Issue: 15 Pages: 3417-3422

    • DOI

      10.1016/j.bmcl.2017.05.087

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic2017

    • Author(s)
      takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
    • Journal Title

      bioorganic medicinal chemistry letter

      Volume: 印刷中 Issue: 11 Pages: 2590-2593

    • DOI

      10.1016/j.bmcl.2017.03.066

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017

    • Author(s)
      Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Med. Chem.

      Volume: 13 Issue: 3 Pages: 206-213

    • DOI

      10.2174/1573406412666160805101408

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2022

    • Author(s)
      福原潔,森一憲,沖山佳生,三澤隆史,水野美麗,出水庸介,柴沼質子,大野彰子
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抗SARS-CoV-2剤創製へ向けた炭素環ヌクレオシドの核酸塩基部構造活性相関研究2022

    • Author(s)
      藤沼舞,石綱遥,三澤隆史,出水庸介,栗原正明,満屋裕明,鍬田伸好,服部真一朗,紺野奇重
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] PreQ1塩基を持つペプチド核酸の合成とその性質2022

    • Author(s)
      森谷俊介,米田有希,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ジフェニルメタン骨格を持つ新規ERαアンタゴニストの創製2022

    • Author(s)
      湯山円晴,三澤隆史,出水庸介,金谷貴行,佐藤忠章,栗原正明
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] In silicoスクリーニングによるSTINGリガンドの効率的探索と機能評価2022

    • Author(s)
      辻厳一郎,栁瀨雄太,柴田識人,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022

    • Author(s)
      柴田識人,横尾英知,遠藤彬則,伊藤貴仁,栁瀨雄太,村上優貴,藤井清永,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 合成オピオイドnitazene類14化合物の識別法に関する検討2022

    • Author(s)
      水谷佐久美,河村麻衣子,黒原崇,三澤隆史,出水庸介,袴塚高志,花尻(木倉)瑠理
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] NMRフィンガープリント法を用いたペプチドの構造変性検出に関する検討2022

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2022

    • Author(s)
      津田萌菜,正田卓司,平田尚也,諫田泰成,井上英史,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 核酸分子の効率的な細胞内送達を可能とする両親媒性ペプチドフォルダマーの開発2022

    • Author(s)
      平野元春,横尾英知,大庭誠,三澤隆史,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] β-カテニンの機能を制御する新規ヘリカルペプチドの開発2022

    • Author(s)
      土屋圭輔,木吉真人,三澤隆史,石井明子,福原潔,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR転写阻害剤の創製2022

    • Author(s)
      田京茉実,三澤隆史,平田尚也,諫田泰成,石田寛明,山本恵子,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] H-PGDS分解誘導剤の構造活性相関研究2022

    • Author(s)
      村上優貴,黒原崇,横尾英知,伊藤貴仁,柳瀬雄太,柴田識人,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022

    • Author(s)
      大澤陽,黒原崇,横尾英知,伊藤貴仁,栁瀨雄太,柴田識人,大槻崇,松藤寛,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 多様なカチオン性アミノ酸を導入した抗菌ペプチドフォルダマーの開発2022

    • Author(s)
      髙田真有,伊藤貴仁,平野元春,土屋圭輔,三澤隆史,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2022

    • Author(s)
      許涵喬,黒原崇,横尾英知,辻厳一郎,柴田識人,大岡伸通,井上貴雄,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高い抗菌活性を有するステープルペプチドの創製2022

    • Author(s)
      伊藤貴仁,三澤隆史,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 動物用ホルモン剤の高純度標品合成と評価に関する研究2022

    • Author(s)
      黒原崇,伊藤貴仁,辻厳一郎,三澤隆史,横尾英知,栁瀨雄太,正田卓司,坂井隆敏,細江潤子,内山奈穂子,穐山浩,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘分子の開発2022

    • Author(s)
      永沼美弥子,大岡伸通,辻村はるな,松野研司,内藤幹彦,井上貴雄,辻厳一郎,出水庸介
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] pecific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022

    • Author(s)
      Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中分子ペプチド医薬品の現状と展望2021

    • Author(s)
      出水庸介
    • Organizer
      第11回CSJ化学フェスタ:バイオ・食品・健康医療、コロナに負けるな!ワクチン・薬分野からの挑戦
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 低分子・中分子医薬品開発効率化に資するレギュラトリーサイエンス研究2021

    • Author(s)
      出水庸介
    • Organizer
      第25回日本がん分子標的治療学会学術集会:RS教育講演
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Rationally designed peptide modulators of amyloid-beta toxicity in Alzheimer’s disease2021

    • Author(s)
      1.Fukuhara, K., Mori, K., Okiyama, Y., Misawa, T., Mizuno, M., Demizu, Y., Shibanuma, M., Ohno, A.
    • Organizer
      AIMECS2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of ciclesonide analogues that block SARS-CoV-2 RNA replication2021

    • Author(s)
      Tsuji, G., Yonemitsu, K., Ito, T., Uema, M., Asakura, H., Demizu, Y.
    • Organizer
      AIMECS2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of helix-stabilized hydrophobic/cationic-block peptides for intracellular delivery of biomacromolecules2021

    • Author(s)
      Misawa, T., Ohoka, N., Hirano, M., Oba, M., Inoue, T., Demizu, Y.
    • Organizer
      AIMECS2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021

    • Author(s)
      Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
    • Organizer
      AIMECS2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Control of N-nitrosodimethylamine (NDMA) in drug substances2021

    • Author(s)
      Yamamoto, E., Yokoo, H., Kan-no, H., Tomita, N., Masada, S., Uchiyama, N., Tsuji, G., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y.
    • Organizer
      The 31st International Symposium on Pharmaceutical and Biomedical Analysis (PBA2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討:qNMRを利用した類縁物質の純度決定2021

    • Author(s)
      辻厳一郎,伊藤貴仁,内山奈穂子,細江潤子,合田幸広,出水庸介
    • Organizer
      第3回日本定量NMR研究会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非天然型構造を有するペプチド医薬品の安全性評価2021

    • Author(s)
      斎藤嘉朗,出水庸介
    • Organizer
      第4回医薬品毒性機序研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021

    • Author(s)
      大岡伸通,永沼美弥子,辻厳一郎,井上貴雄,出水庸介
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ラニチジン不純物からのN-ニトロソジメチルアミン(NDMA)の生成:ラニチジン塩酸塩中にNDMA が存在する潜在的な原因2021

    • Author(s)
      山本栄一,横尾英知,政田さやか,内山奈穂子,辻厳一郎,袴塚高志,出水庸介,伊豆津健一,合田幸広
    • Organizer
      第58回全国衛生科学技術協議会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021

    • Author(s)
      田識人,横尾英知,遠藤彬則,伊藤貴仁,栁瀨雄太,村上優貴,藤井清永,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      第94回日本生化学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] PreQ1 facilitates DNA strand invasion by PNA2021

    • Author(s)
      森谷俊介,桑田啓子,米田有希, 今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021

    • Author(s)
      横尾英知,大岡伸通,大庭誠,伊藤貴仁,井上貴雄,内藤幹彦,出水庸介
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of helical peptides containing non-proteinogenic amino acids inhibiting VDR transcription2021

    • Author(s)
      田京茉実,三澤隆史,黒原崇,石田寛明,山本恵子,出水庸介
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of helical antimicrobial peptides containing non-proteinogenic amino acids2021

    • Author(s)
      平野元春,齋藤千尋,川野竜司,三澤隆史,出水庸介
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] バーチャルスクリーニングを利用した新規STINGリガンドの効率的探索2021

    • Author(s)
      栁瀨雄太,辻厳一郎,柴田識人,出水庸介
    • Organizer
      第47回反応と合成の進歩シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非天然アミノ酸を導入した抗菌ペプチドフォルダマーの開発2021

    • Author(s)
      平野元春,齋藤千尋,川野竜司,三澤隆史,出水庸介
    • Organizer
      第15回バイオ関連化学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] アゴニストリガンドを利用したLXR分解誘導剤の開発2021

    • Author(s)
      許涵喬,辻厳一郎,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021

    • Author(s)
      村上優貴,大澤陽,柴田識人,横尾英知,伊藤貴仁,柳瀬雄太,黒原崇,出水庸介
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ビタミンD受容体転写阻害ペプチドの創製2021

    • Author(s)
      田京茉実,三澤隆史,黒原崇,石田寛明,山本恵子,出水庸介
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発2021

    • Author(s)
      津田萌菜,正田卓司,平田尚也,諫田泰成,井上英史,出水庸介
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アセタール構造を有する新規ERαアンタゴニストの創製2021

    • Author(s)
      湯山円晴,三澤隆史,出水庸介,金谷貴行,佐藤忠章,栗原正明
    • Organizer
      第65回日本薬学会関東支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 非天然アミノ酸の導入による両親媒性抗菌ペプチドフォルダマーの創製2021

    • Author(s)
      平野元春,齋藤千尋,後藤千尋,川野竜司,三澤隆史,出水庸介
    • Organizer
      第52回若手ペプチド夏の勉強会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 胆汁酸受容体TGR5を標的とした新規レチノイド誘導体の創製2021

    • Author(s)
      三澤隆史,照井龍晟,槇島誠,須原義智,出水庸介
    • Organizer
      ケミカルバイオロジー第15回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021

    • Author(s)
      横尾英知,柴田識人,遠藤彬則,伊藤貴仁,柳瀬雄太,村上優貴,藤井清永,大庭誠,佐伯泰,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      ケミカルバイオロジー第15回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヘリカル構造制御に基づく高機能生理活性ペプチドの創出2021

    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第141回年会シンポジウム:中分子創薬研究のフロンティア 生体分子を標的とした機能性ペプチドの創製
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] シリビニンの高機能化を目指した創薬研究2021

    • Author(s)
      水野美麗,森一憲,土屋圭輔,髙木孝士,三澤隆史,出水庸介,柴沼質子,福原潔
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Research-status Report
  • [Presentation] カチオン性グアニンアナログを導入したペプチド核酸オリゴマーによるストランドインベージョンの検討2021

    • Author(s)
      森谷俊介,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗アデノウイルス活性を期待した2’-デオキシ炭素環ヌクレオシドの合成2021

    • Author(s)
      荒井慎之介,斎藤智亜季,水石彩菜,三澤隆史,出水庸介,栗原正明,紺野奇重
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] ペプチドリガンドを利用したタンパク質分解誘導キメラ分子の開発2021

    • Author(s)
      大岡伸通,横尾英知,井上貴雄,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] アミン骨格を有するc-di-GMP誘導体の合成とバイオフィルム形成阻害評価2021

    • Author(s)
      辻厳一郎,池田健太郎,栁瀬雄太,林克彦,工藤由起子,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2021

    • Author(s)
      横尾英知,柴田識人,永沼美弥子,村上優希,藤井清永,伊藤貴仁,有竹浩介,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 5,6,7,8-Tetrahydronaphtalene骨格を用いた選択的TGR5アゴニストの開発2021

    • Author(s)
      三澤隆史,照井龍晟,栁瀨雄太,横尾英知,槇島誠,須原義智,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] LSD類縁体MiPLAの合成とその性状解析2021

    • Author(s)
      正田卓司,河村麻衣子,花尻瑠璃,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 核内受容体を標的とするペプチド型分解誘導剤の開発2021

    • Author(s)
      伊藤貴仁,横尾英知,大岡伸通,内藤幹彦,井上貴雄,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 光異性化に基づくエストロゲン受容体の活性制御2021

    • Author(s)
      土屋圭輔,梅野智大,辻厳一郎,横尾英知,福原潔,三澤隆史,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導剤の創製2021

    • Author(s)
      永沼美弥子,辻村はるな,大岡伸通,松野研司,須原義智,内藤幹彦,上貴雄,辻厳一郎,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 両親媒性抗菌ペプチドフォルダマーの合理的設計2021

    • Author(s)
      平野元春,齋藤千尋,後藤千尋,川野竜司,三澤隆史,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR-コアクチベータ相互作用阻害剤の創製2021

    • Author(s)
      田京茉実,佐藤友海,石田寛明,山本恵子,三澤隆史,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 免疫系制御を指向した新規STINGリガンドの効率的探索2021

    • Author(s)
      栁瀨雄太,池田健太郎,辻厳一郎,柴田識人,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] アプタマーをリガンドとしたエストロゲン受容体分解誘導剤の創製2021

    • Author(s)
      辻村はるな,永沼美弥子,大岡伸通,須原義智,松野研司,内藤幹彦,井上貴雄,辻厳一郎,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] LXRを標的とした分解誘導剤の開発2021

    • Author(s)
      許涵喬,辻厳一郎,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第141回年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2020

    • Author(s)
      出水庸介
    • Organizer
      第10回レギュラトリーサイエンス学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2020

    • Author(s)
      出水庸介
    • Organizer
      第58回日本生物物理学会年会シンポジウム:膜の海を旅するペプチド 脂質膜とペプチドの相互作用研究の新展開
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Temperature-dependent formation of N-nitrosodimethylamine (NDMA) during the storage of ranitidine reagent powders and tablets2020

    • Author(s)
      Abe Y., Yamamoto, E., Yoshida, Masada, S., Yokoo, H., Tsuji, G., Uchiyama, N., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y., Okuda, H.
    • Organizer
      AAPS 2020 PHARMSCI 360
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討:qNMRを利用した類縁物質の純度決定2020

    • Author(s)
      辻厳一郎,伊藤貴仁,内山奈穂子,細江潤子,合田幸広,出水庸介
    • Organizer
      第2回日本定量NMR研究会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非天然型アミノ酸を有するヘリカルペプチドを利用したタンパク質分解誘導キメラ分子の開発2020

    • Author(s)
      大岡伸通,横尾英知,内藤幹彦,井上貴雄,出水庸介
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of stapled peptides against inhibiting VDR-coactivator interaction2020

    • Author(s)
      佐藤友海,田京茉実,三澤隆史,石田寛明,山本恵子,出水庸介
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2020

    • Author(s)
      平野元春,後藤千尋,三澤隆史,出水庸介
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of post-functionalizable antimicrobial peptide foldamers2020

    • Author(s)
      三澤隆史,平野元春,横尾英知,出水庸介
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of peptide-based degraders against estrogen and androgen receptor2020

    • Author(s)
      横尾英知,大岡伸通,内藤幹彦,井上貴雄,出水庸介
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] 中分子ペプチド医薬品の非臨床安全性評価における留意点2020

    • Author(s)
      斎藤嘉朗,出水庸介
    • Organizer
      第10回レギュラトリーサイエンス学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2020

    • Author(s)
      横尾英知,柴田識人,永沼美弥子,伊藤貴仁,内藤幹彦,有竹浩介,出水庸介
    • Organizer
      第64回日本薬学会関東支部大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環7-デアザアデノシンの合成2020

    • Author(s)
      今田敦之,水石彩菜,紺野奇重,三澤隆史,出水庸介,栗原正明,藤井幹雄
    • Organizer
      第64回日本薬学会関東支部大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環ピリミジンヌクレオシドの合成2020

    • Author(s)
      石綱遥,斎藤智亜季,紺野奇重,三澤隆史,出水庸介,栗原正明,藤井幹雄
    • Organizer
      第64回日本薬学会関東支部大会
    • Related Report
      2020 Research-status Report
  • [Presentation] プエラリア・ミリフィカ由来kwakhurinの形式全合成と相対モル感度係数を利用したプエラリア・ミリフィカ含有食品中のmiroestrolの定量2020

    • Author(s)
      政田さやか,遊佐仁曉,辻厳一郎,横尾英知,細江潤子,新井玲子,田中誠司,出水庸介,袴塚高志,合田幸広,内山奈穂子
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] c-di-GMP誘導体の合成とバイオフィルム形成阻害評価2020

    • Author(s)
      池田健太郎,栁瀨雄太,辻厳一郎,林克彦,工藤(原)由起子,出水庸介
    • Organizer
      第34回日本バイオフィルム学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 新規TGR5リガンドの開発2020

    • Author(s)
      三澤隆史,照井龍晟,槇島眞,須原義智,出水庸介
    • Organizer
      日本ビタミン学会第72回大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非天然型構造を有するペプチド医薬品の非臨床評価の方向性2020

    • Author(s)
      斎藤嘉朗,出水庸介
    • Organizer
      第47回日本毒性学会学術年会
    • Related Report
      2020 Research-status Report
  • [Presentation] 国内標品確保のためのフェンタニル構造類似化合物の合成研究2020

    • Author(s)
      辻厳一郎,三澤隆史, 正田卓司,河村麻衣子,花尻(木倉)瑠璃,袴塚高志,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] NMRフィンガープリント法を用いたペプチド医薬品の立体構造解析2020

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Carbocyclic-2'-deoxynucleosideの合成研究 -carbocyclic-2'-deoxyuridineの合成-2020

    • Author(s)
      斎藤智亜季,水石彩菜,目黒公太郎,植松明星,原島利彰,林宏典,児玉栄一,三澤隆史,出水庸介,栗原正明,紺野奇重
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] Carbocyclic-2'-deoxynucleosideの合成研究 -carbocyclic-2'-deoxy-7-deazaadenosineの合成-2020

    • Author(s)
      水石彩菜,斎藤智亜季,目黒公太郎,植松明星,原島利彰,林宏典,児玉栄一,三澤隆史,出水庸介,栗原正明,紺野奇重
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ペプチド核酸によるdouble duplex invasionを応用した目視可能判定可能な一塩基多型検出系の検討2020

    • Author(s)
      森谷俊介,笹祐子,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 疎水性タグを利用したCRABP分解誘導剤の開発2020

    • Author(s)
      正田卓司,大岡伸通,辻厳一郎,井上英史,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 発がん因子BCR-ABLの脱ユビキチン化は慢性骨髄性白血病細胞の増殖に必要である2020

    • Author(s)
      柴田識人,大岡伸通,辻厳一郎,出水庸介,内藤幹彦
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 長鎖アルキル基を有するエストロゲン受容体分解誘導剤のERサブタイプ選択性に関する検討2020

    • Author(s)
      津田萌菜,正田卓司,井上英史,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新しい細胞膜透過性ペプチドフォルダマーの開発と細胞特異的なsiRNAの導入2020

    • Author(s)
      大岡伸通,三澤隆史,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] アミン骨格を利用した環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害評価2020

    • Author(s)
      池田健太郎,栁瀨雄太,辻厳一郎,林克彦,菊池裕,工藤(原)由起子,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] STINGを標的としたCDN誘導体の設計と合成2020

    • Author(s)
      栁瀨雄太,池田健太郎,辻厳一郎,柴田識人,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 核内受容体分解誘導ペプチドの創製2020

    • Author(s)
      横尾英知,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] ステープル構造を持つ抗菌ペプチドフォルダマーの開発2020

    • Author(s)
      平野元春,後藤千尋,林克彦,菊池裕,三澤隆史,工藤由起子,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規TGR5リガンドの開発2020

    • Author(s)
      照井龍晟,三澤隆史,須原義智,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] LXRを標的とした分解誘導剤の開発2020

    • Author(s)
      根本可南子,辻厳一郎,大岡伸通,内藤幹彦,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する研究2020

    • Author(s)
      馬庭愛加,辻厳一郎,内山奈穂子,細江潤子,大槻崇,松藤寛,合田幸広,出水庸介
    • Organizer
      日本薬学会第140回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 非天然型アミノ酸の開発と含有ペプチドの二次構造制御2019

    • Author(s)
      出水庸介
    • Organizer
      CMC+AndTech FORUM特殊ペプチドの合成技術と創薬の最新動向
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019

    • Author(s)
      出水庸介
    • Organizer
      MOEフォーラム2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] M7(R2):「潜在的発がんリスクを低減するための医薬品中DNA反応性(変異原性)不純物の評価及び管理」に対する補遺2019

    • Author(s)
      出水庸介
    • Organizer
      第40回ICH即時報告会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019

    • Author(s)
      出水庸介
    • Organizer
      有機合成化学協会九州山口支部講演会「合成有機化学のフロンティア」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Development of small molecule chimeras that recruit aryl-hydrocarbon receptor (AhR) E3 ligase to induce degradation of target proteins2019

    • Author(s)
      Ohoka, N., Tsuji, G., Shoda, T., Fujisato, T., Kurihara, M., Demizu, Y., Naito, M.
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and synthesis of 4-(2-pyrrolyl)-4-phenylheptane derivatives as estrogen receptor ligands2019

    • Author(s)
      Tsuji, G., Naganuma, M., Yokoo, H., Misawa, T., Matsuno, K., Demizu, Y.
    • Organizer
      17th Annual Discovery on TARGET
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis of alpha-exo-methylene ketones from alpha,alpha-disubstituted allyl alcohols by electrochemical oxidative migration2019

    • Author(s)
      Yamamoto, K., Kikuchi, N., Hamamizu, T., Yoshimatsu, H., Kuriyama, M., Demizu, Y., Onomura, O.
    • Organizer
      The 4th International Symposium on Process Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019

    • Author(s)
      Misawa, T., Ohoka, N., Goto, C., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      European Symposium on Organic Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Peptide foldamers in drug discovery2019

    • Author(s)
      Demizu, Y., Goto, C., Misawa, T., Tsuji, G.
    • Organizer
      26th American Peptide Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of peptide foldamers changing their secondary structures in response to the environmental milieu2019

    • Author(s)
      Oba, M., Furukawa, K., Nonaka, H., Demizu, Y., Tanaka, M.
    • Organizer
      26th American Peptide Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Peptide foldamers in drug discovery2019

    • Author(s)
      Tsuji, G., Misawa, T., Demizu, Y.
    • Organizer
      27th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] フェンタニル類似化合物の化学合成に関する研究2019

    • Author(s)
      辻厳一郎,三澤隆史,河村麻衣子,花尻瑠理,袴塚高志,出水庸介
    • Organizer
      第56回全国衛生科学技術協議会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 医薬品に混入する懸念のあるN-nitrosodimethylamine(NDMA)の迅速分析法の開発2019

    • Author(s)
      政田さやか, 辻厳一郎, 新井玲子, 内山奈穂子, 出水庸介, 袴塚高志, 堤智明, 穐山浩, 阿部康弘, 原矢佑樹, 伊豆津健一, 合田幸広, 奥田晴宏
    • Organizer
      第56回全国衛生科学技術協議会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] siRNAを高効率で細胞内に導入する細胞膜透過性ペプチドフォルダマーの開発2019

    • Author(s)
      大岡伸通,三澤隆史,内藤幹彦,出水庸介
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害能の評価2019

    • Author(s)
      池田健太郎,栁瀨雄太,辻厳一郎,林克彦,菊池裕,工藤由起子,出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] マガイニン2配列を基にした安定化ヘリカルペプチドの開発2019

    • Author(s)
      後藤千尋,平野元春,林克彦,菊池裕,工藤由起子,三澤隆史,出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 芳香族/複素環骨格を有するエストロゲン受容体調整薬の創製2019

    • Author(s)
      永沼美弥子,三澤隆史,辻厳一郎,横尾英知,松野研司,出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] アミロイドβを創薬標的としたシリビニン誘導体の開発2019

    • Author(s)
      水野美麗,森一憲,三澤隆史,高木孝士,出水庸介,柴沼質子,福原潔
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2019

    • Author(s)
      後藤千尋,平野元春,林克彦,三澤隆史,菊池裕,出水庸介
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2019

    • Author(s)
      森谷俊介,笹祐子,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] アミン構造を基盤とした環状ジヌクレオチド等価体の創製2019

    • Author(s)
      栁瀨雄太,池田健太郎,辻厳一郎,林克彦,菊池裕,工藤由起子,出水庸介
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 7-Aminomethyl-7-deazaguanineをもつPNAオリゴマー2019

    • Author(s)
      森谷俊介,柴崎初音,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 強い抗菌活性を示す両親媒性ペプチドフォルダマーの開発2019

    • Author(s)
      後藤千尋,平野元春,林克彦,三澤隆史,菊池裕,出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体高分子を細胞内に導入するキャリアペプチドの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] アミン骨格を基盤とした環状ジヌクレオチド等価体の合成とバイオフィルム形成阻害能の評価2019

    • Author(s)
      池田健太郎,栁瀨雄太,辻厳一郎,林克彦,菊池裕,出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2019

    • Author(s)
      平野元春,後藤千尋,林克彦,三澤隆史,菊池裕,工藤由起子,出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 芳香族複素環を有するエストロゲン受容体アンタゴニストの構造活性相関研究2019

    • Author(s)
      永沼美弥子,横尾英知,三澤隆史,松野研司,辻厳一郎,出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 分析用標品確保のためのフェンタニル構造類似化合物の合成に関する研究2019

    • Author(s)
      辻厳一郎,三澤隆史,河村麻衣子,花尻瑠理,袴塚高志,出水庸介
    • Organizer
      日本法中毒学会第38年会
    • Related Report
      2019 Research-status Report
  • [Presentation] イオンモビリティー質量分析計を用いた生体試料中フェンタニル類スクリーニング分析法の検討2019

    • Author(s)
      河村麻衣子,辻厳一郎,三澤隆史,出水庸介,袴塚高志,花尻瑠理
    • Organizer
      日本法中毒学会第38年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第35回日本DDS学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019

    • Author(s)
      三澤隆史,大岡伸通,後藤千尋,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第14回年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新しいユビキチンリガーゼをリクルートして標的蛋白質を分解するキメラ化合物の開発と抗がん剤としての可能性2019

    • Author(s)
      大岡伸通,辻厳一郎,正田卓司,藤里卓磨,出水庸介,内藤幹彦
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] HPLCによる高血圧治療薬バルサルタン中N-nitrosodimethylamine (NDMA)の迅速定量法2019

    • Author(s)
      内山奈穂子,政田さやか,辻厳一郎,新井玲子,出水庸介,袴塚高志,堤智昭,穐山浩,阿部康弘,伊豆津健一,合田幸広,奥田晴宏
    • Organizer
      第86回日本分析化学会有機微量分析研究懇談会
    • Related Report
      2019 Research-status Report
  • [Presentation] バイオフィルム測定によるMycoplasma pneumoniaeに対する抗菌成分のスクリーニング系の構築2019

    • Author(s)
      林克彦,三澤隆史,後藤千尋,出水庸介,工藤由起子,菊池裕
    • Organizer
      第46回日本マイコプラズマ学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ペプチドフォルダマー創薬研究2019

    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第139回年会シンポジウム:フォルダマーの魅力-新たな創薬への可能性-
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2019

    • Author(s)
      出水庸介
    • Organizer
      第4回レギュラトリーサイエンス公開シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ヘリカルテンプレートペプチドの合成とpost-modificationによる機能化2019

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      日本薬学会第139回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ヘリカル構造に着目した抗菌ペプチドの開発とその毒性評価に関する研究2019

    • Author(s)
      後藤千尋,三澤隆史,菊池裕,出水庸介
    • Organizer
      日本薬学会第139回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規カチオン性グアニンアナログをもつPNAオリゴマー2019

    • Author(s)
      森谷俊介,柴崎初音,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史,杉山亨
    • Organizer
      日本薬学会第139回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019

    • Author(s)
      出水庸介
    • Organizer
      第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会合同会議
    • Related Report
      2018 Research-status Report
  • [Presentation] Helical secondary structures of peptides composed of cyclic amino acids with a chiral acetal moiety2018

    • Author(s)
      Eto, R., Oba, M., Ueda, A., Doi, M., Demizu, Y., Kurihara, M., Tanaka, M.
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of cell-penetrating peptide foldamers for siRNA delivery2018

    • Author(s)
      Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] PNA oligomers possessing PreQ1 as a cationic analogue of guanine2018

    • Author(s)
      Sugiyama, T., Shibasaki, H., Moriya, S., Kuwata, K., Imamura, Y., Demizu, Y., Kurihara, M., Kittaka, T.
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Peptide foldamers in drug discovery2018

    • Author(s)
      Demizu, Y., Misawa, T., Tsuji, G.
    • Organizer
      Bordeaux 2018 Symposium on Foldamers
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Low pH-responsive cyclic alpha,alpha-disubstituted alpha-amino acids for controlling secondary structures of peptide foldamers2018

    • Author(s)
      Oba, M., Furukawa, K., Toyama, K., Opiyo, G. O., Demizu, Y., Kurihara, M., Doi, M., Tanaka, M.
    • Organizer
      Bordeaux 2018 Symposium on Foldamers
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of helix-stabilized amphipathic cell-penetrating peptides for siRNA delivery2018

    • Author(s)
      Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      35th European Peptide Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 正電荷を帯びたグアニン誘導体を持つPNAオリゴマーの合成2018

    • Author(s)
      杉山亨,柴崎初音,森谷俊介,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018

    • Author(s)
      出水庸介,三澤隆史,大岡伸通,服部隆行,内藤幹彦
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 液体クロマトグラフィー/多段階質量分析を利用した特殊環状ペプチドの構造解析2018

    • Author(s)
      橋井則貴,三澤隆史,鈴木琢雄,出水庸介,石井明子
    • Organizer
      第91回日本生化学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 核酸デリバリーを指向した細胞膜高透過性ペプチドフォルダマーの開発2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第62回日本薬学会関東支部大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018

    • Author(s)
      出水庸介,三澤隆史,辻厳一郎
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 側鎖上にキラルなアセタールを有する環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      第48回複素環化学討論会
    • Related Report
      2018 Research-status Report
  • [Presentation] 二次構造制御を基軸とした細胞膜高透過性ペプチドの開発2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Related Report
      2018 Research-status Report
  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発と核酸デリバリーへの応用2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      第34回日本DDS学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018

    • Author(s)
      辻厳一郎,三澤隆史,出水庸介
    • Organizer
      ケミカルバイオロジー第13回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 核酸医薬を細胞内に導入するオリゴペプチドの開発2018

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第13回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 側鎖上にのみ不斉中心を持つ環状ジ置換アミノ酸よりなるヘリカルペプチドの巻き方制御2018

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      第16回次世代を担う有機化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 側鎖にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドのヘリックス二次構造2018

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,田中正一
    • Organizer
      第28回福岡万有シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] タンパク質の寿命を制御できる分子の開発2018

    • Author(s)
      出水庸介
    • Organizer
      生体分子コバレント修飾の革新的解析拠点形成シンポジウム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018

    • Author(s)
      辻厳一郎,小林寛幸,三澤隆史,木下恵愛,松野研司,出水庸介
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018

    • Author(s)
      三澤隆史,諫田泰成,出水庸介
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018

    • Author(s)
      河村麻衣子,三澤隆史,出水庸介,花尻瑠理,袴塚高志
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,宇久翼,田中正一
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      日本薬学会第138回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017

    • Author(s)
      Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
    • Organizer
      Lindau Nobel Laureate Meetings 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Related Report
      2017 Research-status Report
  • [Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017

    • Author(s)
      池田光生,古場百合恵,上田篤志,大庭誠,出水庸介,栗原正明,田中正一
    • Organizer
      第34回日本薬学会九州支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Development of post functionalizable oligopeptides as helical templates2017

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017

    • Author(s)
      古川かほり,大庭誠,遠山琴美,George Ouma Opiyo,出水庸介,栗原正明,土井光暢,田中正一
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,高野真史,橘高敦史
    • Organizer
      第54回ペプチド討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 二次構造制御に基づくペプチド創薬研究2017

    • Author(s)
      出水庸介,三澤隆史,栗原正明
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017

    • Author(s)
      小林寛幸,三澤隆史,松野研司,出水庸介
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017

    • Author(s)
      江藤諒,大庭誠,上田篤志,土井光暢,出水庸介,栗原正明,宇久翼,田中正一
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017

    • Author(s)
      大庭誠,古川かほり,遠山琴美,George Ouma Opiyo,出水庸介,栗原正明,土井光暢,田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017

    • Author(s)
      古場百合恵,上田篤志,大庭誠,出水庸介,土井光暢,田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017

    • Author(s)
      杉山亨,小原美咲,桑田啓子,今村保忠,出水庸介,栗原正明,橘高敦史
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Related Report
      2017 Research-status Report
  • [Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,大庭誠,田中正一,内藤幹彦,松野研司,出水庸介
    • Organizer
      第47回複素環化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通,正田卓司,藤里卓磨,柴田識人,服部隆行,栗原正明,出水庸介,内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,内藤幹彦,出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017

    • Author(s)
      三澤隆史,出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Related Report
      2017 Research-status Report
  • [Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017

    • Author(s)
      小林寛幸,三澤隆史,松野研司,出水庸介
    • Organizer
      第49回若手ペプチド夏の勉強会
    • Related Report
      2017 Research-status Report
  • [Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017

    • Author(s)
      栗原正明,三澤隆史,出水庸介
    • Organizer
      第3回Neo Vitamin D Workshop
    • Related Report
      2017 Research-status Report
  • [Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017

    • Author(s)
      出水庸介,田中理恵,袴塚高志,栗原正明,花尻瑠理
    • Organizer
      日本法中毒学会第36回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017

    • Author(s)
      三澤隆史,小林寛幸,大庭誠,田中正一,栗原正明,出水庸介
    • Organizer
      第33回日本DDS学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017

    • Author(s)
      古場百合恵,池田光生,上田篤志,大庭誠,出水庸介,栗原正明,田中正一
    • Organizer
      第54回化学関連支部合同九州大会
    • Related Report
      2017 Research-status Report
  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017

    • Author(s)
      三澤隆史,出水庸介,栗原正明
    • Organizer
      日本ビタミン学会第69回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017

    • Author(s)
      沖津航陽,服部隆行,三澤隆史,栗原正明,内藤幹彦,出水庸介
    • Organizer
      ケミカルバイオロジー第12回年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017

    • Author(s)
      三澤隆史,大岡伸通,大庭誠,田中正一,内藤幹彦,栗原正明,出水庸介
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Related Report
      2017 Research-status Report
  • [Book] ペプチド創薬の最前線,第5章「二次構造制御を基軸としたペプチド創薬研究」2019

    • Author(s)
      出水庸介
    • Total Pages
      265
    • Publisher
      CMC出版
    • ISBN
      9784781314174
    • Related Report
      2019 Research-status Report
  • [Book] 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略,「ペプチド医薬品の品質に関するガイドラインおよび規制の現状」2019

    • Author(s)
      出水庸介,石井明子
    • Total Pages
      206
    • Publisher
      情報機構
    • ISBN
      9784865021769
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 新規化合物及び医薬組成物2021

    • Inventor(s)
      水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Holder
      水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-115706
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規化合物及び医薬組成物2021

    • Inventor(s)
      2.出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Holder
      2.出水庸介,柴田識人,内藤幹彦,有竹浩介,横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-016808
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 新規化合物及び抗コロナウイルス剤2020

    • Inventor(s)
      出水庸介ら
    • Industrial Property Rights Holder
      出水庸介ら
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-195723
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 構築物,及び,カーゴ分子を細胞内に輸送する方法2018

    • Inventor(s)
      出水庸介,三澤隆史,大岡伸通,内藤幹彦
    • Industrial Property Rights Holder
      出水庸介,三澤隆史,大岡伸通,内藤幹彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-000461
    • Filing Date
      2018
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2023-01-30  

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