Association of bioaerosol in outdoor air with asthma exacerbation

• Project/Area Number: 17K08396
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental and hygienic pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Watanabe Tetsushi 京都薬科大学, 薬学部, 教授 (90182930)
• Co-Investigator(Kenkyū-buntansha): 長谷井 友尋 大阪薬科大学, 薬学部, 准教授 (10388027) ; 松本 崇宏 京都薬科大学, 薬学部, 助教 (30780431)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: リポポリサッカライド / エンドトキシン / タンパク質 / 大気 / 喘息 / たんぱく質 / 大気汚染 / アレルギー・喘息 / 細菌

Outline of Final Research Achievements

We measured the concentrations of airborne protein and endotoxin in outdoor air and analyzed the data on emergency department (ED) visits for asthma at medical centers for long period. Moreover, we collected data on meteorological factors that had been reported to be associated with asthma exacerbation. We examined the association of the levels of these substances and meteorological factors with the number of ED visits for asthma. The results of a Poisson regression analysis indicated that endotoxin was a significant factor for ED visits for asthma. On the other hand, there was no association between protein level and ED visits for asthma.

Academic Significance and Societal Importance of the Research Achievements

これまで、屋内でのアレルゲンタンパク質やエンドトキシンへのばく露が喘息増悪と関連することが明らかにされていたが、大気中のそれらの物質と喘息との関係については不明であった。本研究により、初めて大気中のエンドトキシン濃度と喘息発作患者数の間に有意な正の関連性があることを明らかにした。それらの吸入は、マスク等の着用により容易に防ぐことが可能であることから、本研究成果は喘息発作を予防に貢献することができるものと期待される。

Research Products

• [Journal Article] Relationship of Asian Dust Events with Atmospheric Endotoxin and Protein Levels in Sasebo and Kyoto, Japan, in Spring (2019)
  • Author(s): Mohammad Shahriar Khan, Yuya Deguchi, Takahiro Matsumoto, Hiroaki Nagaoka, Nobuyuki Yamagishi, Keiji Wakabayashi, Tetsushi Watanabe
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 42 Issue: 10 Pages: 1713-1719
  • DOI: 10.1248/bpb.b19-00383
  • NAID: 130007722446
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2019-10-01
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal Fluctuation of Endotoxin and Protein Concentrations in Outdoor Air in Sasebo, Japan (2018)
  • Author(s): Mohammad Shahriar Khan, Souleymane Coulibaly, Maho Abe, Nami Furukawa, Yuuki Kubo, Yusuke Nakaoji, Kawase Yumi, Takahiro Matsumoto, Tomohiro Hasei, Yuya Deguchi, Hiroaki Nagaoka, Nobuyuki Yamagishi, Masanari Watanabe, Naoko Honda, Keiji Wakabayashi, Tetsushi Watanabe
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 41 Issue: 1 Pages: 115-122
  • DOI: 10.1248/bpb.b17-00745
  • NAID: 130006301298
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access
• [Journal Article] Association of airborne particles, protein, and endotoxin with emergency department visits for asthma in Kyoto, Japan (2018)
  • Author(s): Mohammad Shahriar Khan, Souleymane Coulibaly, Takahiro Matsumoto, Yoshitaka Yano, Makoto Miura, Yukio Nagasaka, Masayuki Shima, Nobuyuki Yamagishi, Keiji Wakabayashi, Tetsushi Watanabe
  • Journal Title: Environmental Health and Preventive Medicine Volume: 23 Issue: 1 Pages: 41-41
  • DOI: 10.1186/s12199-018-0731-2
  • NAID: 50012994951
  • Peer Reviewed / Open Access
• [Presentation] Association between atmospheric air pollutants and emergency department child patients visits for asthma in Sasebo, Japan (2019)
  • Author(s): Mohammad Shahriar Khan, Takahiro Matsumoto, Tetsushi Watanabe et al.
  • Organizer: フォーラム2019 衛生薬学・環境トキシコロジー
• [Presentation] Relationship of atmospheric protein, endotoxin, and meteological factors with emergency department visits for asthma in Kyoto, Japan (2019)
  • Author(s): Mohammad Shahriar Khan, Takahiro Matsumoto, Tetsushi Watanabe et al.
  • Organizer: 第31回微生物シンポジウム
• [Presentation] Relationship between Atmospheric Environmental Factors and Emergency Department Visits for Asthma in Kyoto, Japan. (2018)
  • Author(s): Mohammad Shahriar Khan, Souleymane Coulibaly, Takahiro Matsumoto, Yoshitaka Yano, Makoto Miura, Yukio Nagasaka, Masayuki Shima, Nobuyuki Yamagishi4, Keiji Wakabayashi, Tetsushi Watanabe:
  • Organizer: フォーラム2018衛生薬学・環境トキシコロジー
• [Presentation] 京都市における大気粉塵中のエンドトキシン等の濃度と喘息患者数の関連性 (2018)
  • Author(s): 出口のぞみ、河瀬裕美、永縄壮一郎、北川貴大、Mohammad Shahriar Khan、三浦 誠、長坂行雄、松本崇宏、渡辺徹志
  • Organizer: 第68回日本薬学会近畿支部総会・大会
• [Presentation] 春季及び秋季の九州北部における大気粉塵中のエンドトキシン、タンパク質、イオンの定量分析 (2018)
  • Author(s): 永縄壮一朗、北川貴大、出口のぞみ、岡橋和佳奈、Mohammad Shahriar Khan、山村由貴、世良暢之、後藤貴央、平川雅章、松本崇宏、渡辺徹志
  • Organizer: 第68回日本薬学会近畿支部総会・大会
• [Presentation] 姫路市における大気粉塵中のエンドトキシン、タンパク質等と喘息発作との関連性 (2018)
  • Author(s): 北川貴大、出口のぞみ、永縄壮一朗、Mohammad Shahriar Khan、高橋亮平、松岡洋平、島 正之、松本崇宏、渡辺徹志
  • Organizer: 第68回日本薬学会近畿支部総会・大会
• [Presentation] 大気粉塵の化学・生物学的成分による汚染とその生体影響 (2017)
  • Author(s): 渡辺徹志
  • Organizer: 第44回日本毒性学会
• [Presentation] Seasonal Fluctuation of the Concentrations of Endotoxin, Protein and Ionic Substances in Outdoor Air and their Effect on Asthmatic Patients. (2017)
  • Author(s): Mohammad Shahriar Khan, Nami Furukawa, Yuuki Kubo, Yusuke Nakaoji, Yumi Kawase, Tomohiro Hasei, Takahiro Matsumoto, Yoshitaka Yano, Yuya Deguchi, Hiroaki Nagaoka, Makoto Miura, Yukio Nagasaka, Nobuyuki Yamagishi, Tetsushi Watanabe
  • Organizer: フォーラム2017衛生薬学・環境トキシコロジー
• [Presentation] 西日本における大気中のタンパク質、エンドトキシン、イオン類の濃度の季節的変動と長距離輸送の影響. (2017)
  • Author(s): 渡辺徹志、Khan Mohammad Shahriar、古川奈美、久保裕希、中大路友亮、河瀬裕美、長谷井友尋、松本 崇宏、出口 雄也、長岡 寛明、山岸 伸行
  • Organizer: 第58回大気環境学会