Analysis of the mechanism of progression of pneumonia in the initial infection of RSV
| Project/Area Number |
17K08405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
Watanabe Wataru 九州保健福祉大学, 保健科学部, 教授 (50399218)
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| Co-Investigator(Kenkyū-buntansha) |
明石 敏 九州保健福祉大学, 薬学部, 教授 (10648596)
宮内 亜宜 九州保健福祉大学, 薬学部, 助教 (70736488)
黒川 昌彦 九州保健福祉大学, 薬学部, 教授 (80186527)
吉田 裕樹 九州保健福祉大学, 薬学部, 准教授 (90469411)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | RSウイルス / 肺炎 / RSV / 肺炎球菌 / RANTES / 感染症 / ウイルス |
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| Outline of Final Research Achievements |
To reveal the initial mechanism of RSV-induced pneumonia, we evaluated the effects of formalin-inactivated streptococcus pneumoniae (ISP) on pneumonia in RSV-infected mice. It was revealed that ISP enhanced the production of a chemokine RANTES from alveolar macrophages due to ingestion of the intact fungus body. Because type-I interferon was not induced due to ISP administration in RSV-infected mice, it was suggested that progression of pneumonia was alleviated due to activation of an initial immune response in RSV infection. Although enhancement of the induction of RANTES due to ISP was confirmed in RSV-infected RAW264.7 cells in vitro, improvement of efficacy of ISP was not found using various strains of streptococcus pneumoniae. Further study needs to be done to find new anti-RS viral materials using streptococcus pneumoniae.
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| Academic Significance and Societal Importance of the Research Achievements |
RSウイルスは、小児において上・下気道炎など呼吸器疾患を引き起こす。近年、冬季を中心に高齢者を含めて大流行が報告されており、ワクチンがなく肺炎など重症化症例数の増加と共に医療行政上の重要な問題になっている。
本研究では、ワクチン開発の障害になったRSウイルスの特徴的な細胞性免疫、特に感染初期応答のメカニズムについて不活化肺炎球菌をツールに解析することに取り組んだ。結果として、防御可能な素材の有望な候補は見いだせなかったが、RANTESが肺炎進行の鍵とであり防御の標的になる可能性を示し、今後のワクチンや抗ウイルス薬の開発などに貢献できると考えている。
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Effect of inactivated Streptococcus pneumoniae as non-pathogenic particles on the severity of pneumonia caused by respiratory syncytial virus infection in mice2019
Author(s)
Miyauchi, A., Watanabe, W., Akashi, T., Hashiguchi, S., Yoshida, H., Sugita, C., Kurokawa,
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Journal Title
Toxicology Report
Volume: 6
Pages: 514-520
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, exacerbated the pneumonia in respiratory syncytial virus (RSV)-infected offspring mice2017
Author(s)
3)Watanabe W, Hirose A, Takeshita T, Hashiguchi S, Sakata K, Konno K, Miyauchi A, Akashi T, Yoshida H, Sugita C, Kurokawa M.
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Journal Title
The Journal of Toxicological Sciences
Volume: 42
Issue: 6
Pages: 789-795
DOI
NAID
ISSN
0388-1350, 1880-3989
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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