Evaluation of cubic-phase drug-carrier nanoparticles

• Project/Area Number: 17K08467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Toho University
• Principal Investigator: NOGUCHI Shuji 東邦大学, 薬学部, 教授 (60237823)
• Co-Investigator(Kenkyū-buntansha): 伊藤 雅隆 東邦大学, 薬学部, 助教 (30792410)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: Ｘ線吸収スペクトル法 / Ｘ線吸収端近傍構造 / Ｘ線吸収スペクトル測定法 / 薬物担体 / 物性評価 / 難溶性薬物の可溶化 / 新規薬物担体

Outline of Final Research Achievements

X-ray absorption near-edge structure (XANES) spectroscopy was applied to evaluate the active pharmaceutical ingredients for the first time. The method could reveal the chemical environment of the X-ray absorbing atoms, indicating that the method would be a potent method for evaluating the APIs in pharmaceutics including cubic-phase nanoparticles.

Academic Significance and Societal Importance of the Research Achievements

X線吸収端近傍構造（XANES）測定法は、固形製剤から液状製剤まで、様々な形態の製剤中の医薬品原薬の分析が可能であり、医薬品製剤のより精密な評価に適用できると期待できる。

Research Products

• [Journal Article] 1.Chlorine K-edge X-ray absorption near-edge structure analysis of clarithromycin hydrochloride metastable crystal. (2020)
  • Author(s): MasatakaIto, Rika Shiba, Hironori Suzuki, Shuji, Noguchi
  • Journal Title: Journal of Pharmaceutical Science Volume: 109 Issue: 6 Pages: 2095-2099
  • DOI: 10.1016/j.xphs.2020.03.015
  • Peer Reviewed
• [Journal Article] Crystal Structures of Flavone <i>C</i>-Glycosides from Oolong Tea Leaves: Chafuroside A Dihydrate and Chafuroside B Monohydrate (2019)
  • Author(s): Iwao Yasunori、 Ishida Hitoshi、Kimura Shin-ichiro、Wakimoto Toshiyuki、Kondo Hiromu、Itai Shigeru、Noguchi Shuji
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 67 Issue: 9 Pages: 935-939
  • DOI: 10.1248/cpb.c19-00166
  • NAID: 130007699653
  • ISSN: 0009-2363, 1347-5223
  • Year and Date: 2019-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Desolvation behavior of indinavir sulfate ethanol and follow-up by terahertz spectroscopy (2019)
  • Author(s): Ito Masataka、Tokuda Reiko、Suzuki Hironori、Sakamoto Tomoaki、Terada Katsuhide、Noguchi Shuji
  • Journal Title: International Journal of Pharmaceutics Volume: 567 Pages: 118446-118446
  • DOI: 10.1016/j.ijpharm.2019.06.037
  • Peer Reviewed
• [Journal Article] Phase transitions of antibiotic clarithromycin forms I, IV and new form VII crystals (2018)
  • Author(s): Ito Masataka、Shiba Rika、Watanabe Miteki、Iwao Yasunori、Itai Shigeru、Noguchi Shuji
  • Journal Title: International Journal of Pharmaceutics Volume: 547 Issue: 1-2 Pages: 258-264
  • DOI: 10.1016/j.ijpharm.2018.05.073
  • Peer Reviewed
• [Presentation] Cl含有医薬品原薬 (2019)
  • Author(s): 岩戸萌美，鈴木浩典，伊藤雅隆，野口修治
  • Organizer: 日本薬学会第139年会
• [Presentation] XAFSを用いたエレトリプタン臭化水素酸塩の結晶多形の評価 (2019)
  • Author(s): 冨田明日美, 伊藤雅隆, 鈴木浩典, 野口 修治
  • Organizer: 日本薬学会第139年会
• [Presentation] X線吸収端近傍構造スペクトル測定によるClまたはS含有医薬品原薬結晶多形の評価 (2019)
  • Author(s): 鈴木浩典、岩田萌美、伊藤雅隆、野口修治
  • Organizer: 日本薬剤学会第34年会
• [Presentation] 塩溶媒和物結晶のX線吸収端近傍構造スペクトル測定を用いた評価 (2018)
  • Author(s): 伊藤 雅隆、朱芳黎、野口修治
  • Organizer: 日本薬剤学会第33年会
• [Presentation] 医薬品原薬塩酸塩結晶のX線吸収端近傍構造スペクトル測定 (2018)
  • Author(s): 司馬理佳，伊藤雅隆，野口修治
  • Organizer: 日本薬剤学会第33年会
• [Presentation] 柑橘類果皮由来フラボノイドノビレチンの共結晶調製と物性評価 (2018)
  • Author(s): 徳永将大，伊藤雅隆，野口修治
  • Organizer: 日本薬学会第138年会
• [Presentation] クラリスロマイシン準安定I型結晶の吸湿による転移過程の解析 (2018)
  • Author(s): 司馬理佳，伊藤雅隆，渡邉美笛，岩尾康範，板井茂，野口修治
  • Organizer: 日本薬学会第138年会
• [Remarks] 東邦大学薬学部薬剤学教室 研究業績
  • URL: https://www.lab.toho-u.ac.jp/phar/yakuzai/article/index.html