| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Adverse events of amiodarone-induced NASH were examined using spontaneous adverse event database. We showed that positive signal detection for amiodarone-associated NASH, and those data suggested that amiodarone are strongly associated with an increased risk of NASH. In addition, the expression of drug-metabolizing enzymes and transporters associated with bile transport were reduced in the liver of mice with NASH. These results indicate the possible dysfunction of drug metabolism and enterohepatic circulation in the NASH. We showed that this mechanism is likely associated with disruption of small intestinal barrier function.
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