Effects of GLP-1 on cardiac function = analysis in the stimulated conduction system using magnetocardiography =

• Project/Area Number: 17K08484
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Tamanaha Tamiko 国立研究開発法人国立循環器病研究センター, 病院, 医師 (50791844)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ２型糖尿病 / 心磁図 / GLP-1 / 心血管疾患 / 2型糖尿病 / ANP３分子型 / ANP3分子型 / ＡＮＰ3分子型 / 糖尿病 / 臨牀 / 薬剤反応性

Outline of Final Research Achievements

This study investigated the benefit of GLP-1 treatment on cardiovascular events in patients with type 2 diabetes mellitus, focusing on its effects on the stimulatory conduction system. Magnetocardiograms were performed before and 24 weeks after administration of GLP-1. No obvious changes were observed in various parameters before and after administration of GLP-1.Although this study did not elucidate the mechanism regarding the suppression of cardiovascular events, the suppression of cardiovascular events in diabetic patients is an important issue.

Academic Significance and Societal Importance of the Research Achievements

GLP-1製剤は膵β細胞に発現するGLP-1受容体に作用してインスリン分泌を促進し血糖降下作用を示す。GLP-1には膵外作用があり、心保護作用も報告されている。一方、心不全のリスク因子である心拍数の上昇作用についても知られているが、その機序はまだ明らかにされていない。今回の研究では、GLP-1製剤治療で、心磁図を用いて刺激伝導系への作用を検討したが、心血管イベント抑制に関する機序の解明には至らなかったが、増加する糖尿病患者の心血管イベント抑制の機序の解明は医療および社会的意義を有する。

Research Products

• [Journal Article] Diabetic microvascular complications predicts non‐heart failure with reduced ejection fraction in type 2 diabetes (2023)
  • Author(s): Tochiya Mayu、Makino Hisashi、Tamanaha Tamiko、Omura‐Ohata Yoko、Matsubara Masaki、Koezuka Ryo、Noguchi Michio、Tomita Tsutomu、Asaumi Yasuhide、Miyamoto Yoshihiro、Yasuda Satoshi、Hosoda Kiminori
  • Journal Title: ESC Heart Failure Volume: 10 Issue: 2 Pages: 1158-1169
  • DOI: 10.1002/ehf2.14280
  • Peer Reviewed / Open Access
• [Journal Article] A Prospective Longitudinal Study on the Relationship Between Glucose Fluctuation and Cognitive Function in Type 2 Diabetes: PROPOSAL Study Protocol (2020)
  • Author(s): Matsubara Masaki、Makino Hisashi、Washida Kazuo、Matsuo Miki、Koezuka Ryo、Ohata Yoko、Tamanaha Tamiko、Honda-Kohmo Kyoko、Noguchi Michio、Tomita Tsutomu、Son Cheol、Nakai Michikazu、Nishimura Kunihiro、Miyamoto Yoshihiro、Ihara Masafumi、Hosoda Kiminori
  • Journal Title: Diabetes Therapy Volume: 11 Issue: 11 Pages: 2729-2737
  • DOI: 10.1007/s13300-020-00916-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type?2 diabetes and heart diseases: A pilot study (2019)
  • Author(s): Tochiya Mayu、Makino Hisashi、Tamanaha Tamiko、Matsuo Miki、Hishida Ai、Koezuka Ryo、Ohata Yoko、Tomita Tsutomu、Son Choel、Miyamoto Yoshihiro、Yasuda Satoshi、Hosoda Kiminori
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 2 Pages: 400-404
  • DOI: 10.1111/jdi.13122
  • Peer Reviewed / Open Access
• [Journal Article] The efficacy of glycemic control with continuous glucose monitoring on atheroma progression: rationale and design of the Observation of Coronary Atheroma Progression under Continuous Glucose Monitoring Guidance in Patients with Type 2 Diabetes Mellitus (OPTIMAL) (2019)
  • Author(s): Kataoka Yu、Hosoda Kiminori、Makino Hisashi、Matsubara Masaki、Matsuo Miki、Ohata Yoko、Koezuka Ryo、Tamanaha Tamiko、Tomita Tsutomu、Honda-Kohmo Kyoko、Noguchi Michio、Son Cheol、Nishimura Kunihiro、Asaumi Yasuhide、Miyamoto Yoshihiro、Noguchi Teruo、Yasuda Satoshi
  • Journal Title: Cardiovascular Diagnosis and Therapy Volume: 9 Issue: 5 Pages: 431-438
  • DOI: 10.21037/cdt.2019.09.02
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of visceral fat estimation by dual bioelectrical impedance analysis in detecting cardiovascular risk factors in patients with type 2 diabetes (2019)
  • Author(s): Omura-Ohata Yoko、Son Cheol、Makino Hisashi、Koezuka Ryo、Tochiya Mayu、Tamanaha Tamiko、Kishimoto Ichiro、Hosoda Kiminori
  • Journal Title: Cardiovascular Diabetology Volume: 18 Issue: 1 Pages: 137-137
  • DOI: 10.1186/s12933-019-0941-y
  • Peer Reviewed / Open Access
• [Journal Article] Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study). (2019)
  • Author(s): 6.Makino H, Tanaka A, Asakura K, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Son C, Shimabara Y, Fujita T, Miyamoto Y, Kobayashi J, Hosoda K.
  • Journal Title: Diabet Med. Volume: 36(12) Issue: 12 Pages: 1621-1628
  • DOI: 10.1111/dme.14084
  • Peer Reviewed / Open Access
• [Journal Article] Effect of linagliptin on oxidative stress markers in patients with type 2 diabetes:a pilot study. (2019)
  • Author(s): 8.H. Makino, M. Matsuo, A. Hishida, R. Koezuka, M. Tochiya, Y. Ohata, T. Tamanaha, C. Son, Y. Miyamoto, K. Hosoda.
  • Journal Title: Diabetol Int Volume: 10(2) Issue: 2 Pages: 148-152
  • DOI: 10.1007/s13340-018-0376-9
  • Peer Reviewed / Open Access
• [Journal Article] Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study (2019)
  • Author(s): Tochiya, Mayu; Makino, Hisashi; Tamanaha, Tamiko; Matsuo, Miki; Hishida, Ai; Koezuka, Ryo; Ohata, Yoko; Tomita, Tsutomu; Son, Cheol; MIyamoto, Yoshihiro; Yasuda, Satoshi; Hosoda, Kiminori
  • Journal Title: Journal of Diabetes Investigation Volume: in press
  • Peer Reviewed
• [Journal Article] LDL apheresis in Japan (2017)
  • Author(s): Makino H, Tamanaha T, Harada-Shiba M.
  • Journal Title: Transfus Apher Sci. Volume: 56 Issue: 5 Pages: 677-681
  • DOI: 10.1016/j.transci.2017.08.014
  • Peer Reviewed / Open Access
• [Presentation] 心疾患合併糖尿病糖尿病患者におけるトホグリフロジンの心血管機能に及ぼす影響 (2019)
  • Author(s): 槇野 久士、橡谷 真由、玉那覇 民子、松尾 実紀、河面 恭子、肥塚 諒、松原 正樹、大畑 洋子、野口 倫生、冨田 努、 孫 徹、安田 聡、細田 公則
  • Organizer: 糖尿病学会総会
• [Presentation] 2型糖尿病患者における糖尿病網膜症の進行度と拡張不全型心不全の (2018)
  • Author(s): 橡谷真由、松尾実紀、河面恭子、肥塚諒、大畑洋子、玉那覇民子、野口倫生、冨田努、槇野久士、孫徹、細田公則
  • Organizer: 2018年 日本糖尿病学会総会
• [Presentation] PCSK9抗体治療によりLDLアフェレシスを離脱し得た家族性高コレステロール血症の7例 (2017)
  • Author(s): 玉那覇民子、松尾実紀、肥塚諒、橡谷真由、大畑洋子、冨田努、小倉正恒、槇野久士、孫徹 、細田公則、斯波真理子
  • Organizer: 2017年 動脈硬化学会総会
• [Presentation] 心臓外科手術周術期血糖管理におけるリラグリチドの有用性の検討 (2017)
  • Author(s): 槇野久士、、松尾実紀、肥塚諒、橡谷真由、大畑洋子、玉那覇民子、孫徹 、島原祐介、藤田知之、小林順二郎、細田公則
  • Organizer: 2017年 糖尿病学会総会