Mechanisms of neural development and autism spectrum disorders mediated by neural specific kinase
| Project/Area Number |
17K08492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Hiroshima University |
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Principal Investigator |
Suzuki Atsushi 広島大学, 両生類研究センター, 准教授 (20314726)
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| Co-Investigator(Kenkyū-buntansha) |
竹林 公子 (鈴木) 広島大学, 両生類研究センター, 研究員 (00397910)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 自閉症 / 神経形成 / 誘導因子シグナル / 発生・分化 |
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| Outline of Final Research Achievements |
To understand the embryonic etiology linked to autism spectrum disorders, we analyzed the function of neural specific kinase (Nsk)/Clk2 during neural development of vertebrate embryos. Overexpression of Nsk/Clk2 in Xenopus embryos caused the expansion of neural tissues, while chemical inhibition of Nsk/Clk2 affected neural tissue formation during development. Mechanistically, we found that Nsk/Clk2 promotes neural tissue formation via modulation of the BMP and FGF signaling pathways. In the future, our findings will help the development of better treatments for autism spectrum disorders in human.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果によって、自閉症治療薬の創薬ターゲットであるNsk/Clk2の神経発生における役割と誘導因子シグナルの調節機構が明確になった。今後、Nsk/Clk2が誘導因子シグナル伝達因子（Smad, MAPK）のリン酸化やタンパク質安定性を制御するメカニズムを詳細に解析することで、副作用が少なく効果的な自閉症治療薬の開発に貢献することが期待される。
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] The AP-1 transcription factor JunB functions in Xenopus tail regeneration by positively regulating cell proliferation2020
Author(s)
Nakamura, M., Yoshida, H., Takahashi, E., Wlizla, M., Takebayashi-Suzuki, K., Horb, M. E. and Suzuki, A.
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 522
Issue: 4
Pages: 990-995
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The autism-related gene cdc-like kinase 2 (clk2) promotes early neural development via modulation of morphogen signals in Xenopus embryos2019
Author(s)
Regina Putri Virgirinia, Nusrat Jahan, 岡田麻耶, 竹林公子, 吉田和史, 中村 誠, 赤尾 元, 吉元雄太, Fatchiyah Fatchiyah, 上野直人, 鈴木 厚
Organizer
第13回日本ツメガエル研究集会
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[Presentation] Geneolgy and pedigrees of inbreeding strains of Xenopus tropicalis2018
Author(s)
Takeshi Igawa, Akihiko Kashiwagi, Keiko Kashiwagi, Nanoka Suzuki, Ai Watanabe, Atsushi Suzuki, Anna Noble, Matt Guille, David E. Simpson, Marko E. Horb, Tamotsu Fujii, Masayuki Sumida, Hajime Ogino
Organizer
17th International Xenopus Conference
Related Report
Int'l Joint Research
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[Presentation] Neural specific kinase promotes early neural development in Xenopus embryos2018
Author(s)
Regina Putri Virgirinia, Nusrat Jahan, Maya Okada, Kimiko Takebayashi-Suzuki, Hitoshi Yoshida, Makoto Nakamura, Hajime Akao, Fatchiyah Fatchiyah, Naoto Ueno and Atsushi Suzuki
Organizer
Hiroshima University International Symposium: Amphibian development, regeneration, evolution and beyond
Related Report
Int'l Joint Research
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[Presentation] Neural specific kinase promotes early neural development in Xenopus embryos2017
Author(s)
Jahan, N., Virgirinia, R.P., Takebayashi-Suzuki, K., Okada, M., Yoshida, H., Akao, H., Fatchiyah, F., Ueno, N. and Suzuki, A.
Organizer
第50回発生生物学会大会
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