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Analysis of sympathetic nerve endings distribution patterns and their functional control in normal and pathological conditions of the kidney

Research Project

Project/Area Number 17K08501
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionHyogo Medical University

Principal Investigator

Maeda Seishi  兵庫医科大学, 医学部, 准教授 (10309445)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腎臓 / 交感神経系 / 神経終末 / シュワン細胞 / インテグリン / 自律神経系 / 腎傷害 / シナプス / 免疫電顕 / 軸索瘤 / 交感神経 / 終末 / varicosity / チロシン水酸化酵素 / 虚血 / 神経科学
Outline of Final Research Achievements

It is known that renal sympathetic hyperactivity occurs during kidney injury and exacerbates renal dysfunction. However, the properties of renal sympathetic nerve terminals and the transitions during injury is still unclear. In this study, the fine morphology and molecular property of the maintenance of rat renal sympathetic nerves are examined. Furthermore, we tried to preparate the ischemia/reperfusion (I/R) rats preserving their renal nerves.Single-labeled renal sympathetic nerve axon formed a nerve bundle with unlabeled-axons and projected into vascular smooth muscle and tubules while forming axonal varicosities. These endings were attached to the basement membrane fibronectin by the integrin α4β1.
RNP rats were useful as a model in the present study because the experimental I/R treatment had less effect on the renal nerves than the conventional 2 kidney 1 clipping method.

Academic Significance and Societal Importance of the Research Achievements

腎臓の交感神経は体液の浸透圧調節をはじめ、血圧調節などに重要である反面、その活動亢進により腎機能障害の増悪や高血圧を引き起こす要因にもなる。本研究は、投射の複雑な腎臓の交感神経終末構築の微細形態的および分子生物学的基盤を明らかにしつつ、傷害腎モデル動物の作出を試みたものである。本研究で得られた基礎的なデータは、複雑な腎臓の自律神経支配のメカニズムの解明に役立つのみならず、腎交感神経をターゲットとした高血圧治療や腎移植時の腎神経再生誘導などに応用できるだろう。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Differential Distribution of Renal Nerves in the Sympathetic Ganglia of the Rat2017

    • Author(s)
      Maeda Seishi、Fujihira Mayumi、Minato Yusuke、Kuwahara-Otani Sachi、Tanaka Koichi、Hayakawa Tetsu、Yagi Hideshi
    • Journal Title

      The Anatomical Record

      Volume: 300 Issue: 12 Pages: 2263-2272

    • DOI

      10.1002/ar.23680

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 成体ラット腎臓における神経終末の構造およびインテグリンの発 現と分布2020

    • Author(s)
      前田誠司、堀日和、湊 雄介、大谷佐知、八木秀司
    • Organizer
      第125回日本解剖学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Morphological and molecular characteristics of renal sympathetic nerve endings attached to multi-effector modules2019

    • Author(s)
      Seishi Maeda, Hiyori Hori, Mayumi Fujihira, Yusuke Minato, Sachi Kuwahara-Otani, Hideshi Yagi
    • Organizer
      Neuroscience 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腎臓における交感神経終末の分布様式とその形態について2019

    • Author(s)
      前田 誠司、堀 日和、湊 雄介、大谷 佐知、八木 秀司
    • Organizer
      第124回日本解剖学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] ラット虚血/再灌流傷害腎における2 kidney-1 clipping法の腎神経温存法と従来法との比較2018

    • Author(s)
      前田 誠司、藤平 真弓、堀 日和、湊 雄介、大谷 佐知、八木 秀司
    • Organizer
      第123回日本解剖学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Innervation of suprarenal ganglion neurons to the visceral organs ~Anterograde and retrograde tracing study in the rat sympathetic nerves.2017

    • Author(s)
      Seishi Maeda, Mayumi Fujihira, Yusuke Minato, Sachi Kuwahara-Otani, Hideshi Yagi.
    • Organizer
      第40回日本神経科学会大会
    • Related Report
      2017 Research-status Report

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Published: 2017-04-28   Modified: 2021-02-19  

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