Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
The slit diaphragms of podocytes function as a glomerular filtration barrier to prevent leakage of plasma proteins into the urine. The slit diaphragm is formed during podocyte development and disappears and regenerates during pathologic condition. These three morphological processes of the slit diaphragm alteration are only fragmentarily understood. In this study, we utilized volume electron microscopy (FIB/SEM tomography) to fully elucidate the 3D morphological processes of slit film formation, loss, and regeneration.
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