Neuronal mechanisms of taste information processing in the insular cortex
Project/Area Number |
17K08538
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | Osaka University |
Principal Investigator |
Toyoda Hiroki 大阪大学, 歯学研究科, 准教授 (00432451)
|
Project Period (FY) |
2017-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | カプサイシン受容体 / カンナビノイド受容体 / うま味受容体 / 興奮伝播 / パッチクランプ / 島皮質 / 光学的膜電位測定法 / 味覚情報処理 / カプサイシン / カンナビノイド / うま味 / オシレーション / Gタンパク質 / 情報処理 / 局所神経回路 / 味覚 / チャネル / 神経回路 / 錐体細胞 / イオンチャネル / 味覚受容 / 受容体 / 摂食 / ネットワーク / 自律神経応答 |
Outline of Final Research Achievements |
The taste-related receptors are expressed in the central nervous system, but their physiological roles are largely unknown. In this study, the functional roles of TRPV1, CB1 and T1R1/T1R3 receptors expressed in the rat insular cortex were studied using electrophysiological methods. It is possible that when these receptors are activated, the excitation arising from the taste insular cortex propagates into the autonomic insular cortex, causing modulation of food intake and autonomic activities.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究では、島皮質味覚野に発現している味覚関連受容体(TRPV1受容体、CB1受容体、T1R1/T1R3受容体)の生理学的役割の一端を明らかにした。一般的に味覚関連受容体は、末梢神経系において中心的な役割果たすと考えられているが、中枢神経系においても重要な役割を果たしている可能性を明らかにしたため、学術的意義が高い。高次脳における味覚関連受容体の生理学的役割を明らかにすることで、健康増進に寄与することが期待される。
|
Report
(5 results)
Research Products
(28 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Inhibition of GluR Current in Microvilli of Sensory Neurons via Na(+)-Microdomain Coupling among GluR, HCN channel and Na(+)/K(+) Pump.2018
Author(s)
Kawasaki Y, Saito M, Won J, Bae JY, Sato H, Toyoda H, Kuramoto E, Kogo M, Tanaka T, Kaneko T, Oh SB, Bae YC, Kang Y.
-
Journal Title
Front. Cell. Neurosci.
Volume: 印刷中
Pages: 113-113
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
[Journal Article] A distinct functional distribution of α and γ motoneurons in the rat trigeminal motor nucleus.2017
Author(s)
Morita-Isogai, Y., Sato, H., Saito, M., Kuramoto, E., Yin, D., Kaneko, T., Yamashiro, T., Takada, K., Oh, S.B., Toyoda, H., & Kang, Y.
-
Journal Title
Brain Structure and Function
Volume: -
Issue: 7
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-