| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The hypophagia/anorexia exacerbates the health conditions, however, there is no effective therapeutic medicine to treat the eating disorder. This study demonstrated that diallyl trisulfide (DATS), which is one of characteristic ingredient and potent TRPA1 agonist in the garlic, increased food intake by interacting with TRPA1-expressing and novel subclass of vagal afferents with orexigenic role. Moreover, DATS enhanced food intake in hypophagic model mice (stress and aging). Therefore, DATS and/or the method of activation of TRPA1-expressing vagal afferents might be effective in treating hypophagia/anorexia and its related disorder.
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