| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Since there is no invasion of blood vessels into the mesenchymal tissues at the time when the cartilage primordia are formed, it is suggested that the mesenchymal cells around the cartilage primordia are producing the morphogenetic factors related to the cartilage primordia. As a result of visualizing the cartilage primordia in the embryonic period and surrounding mesenchymal cells, it was found that the expression of cartilage primordia was different in each site. Moreover, histological observation revealed the localization of PDGFRα-positive cells at the interface between the cartilage primordia and the surrounding cell group, suggesting the involvement of PDGF. The cartilage could be visualized from the three-dimensional analysis, and the findings regarding the localization elucidation of morphogenetic factors using immunostaining were obtained.
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